{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:42:32Z","timestamp":1792226552869,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cerebral cavernous malformations (CCMs) are vascular anomalies frequently associated with drug\u2010resistant epilepsy. Surgical resection is a well\u2010established treatment; however, the optimal strategy to achieve long\u2010term seizure freedom (SF) remains unclear. Intraoperative electrocorticography (ECoG) may enhance seizure outcome by guiding resection extent, yet comparative evidence is limited. To evaluate the efficacy of ECoG\u2010guided resection in patients with CCMs, a single\u2010center comparative retrospective cohort analysis and a meta\u2010analysis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 67 adult patients with CCMs who underwent resective surgery with or without ECoG guidance at our institution. The primary outcome of interest was SF. Statistical analysis included univariate analysis, Kaplan\u2013Meier and receiver operating characteristic curves, and uni\u2010 and multivariate logistic regression. Additionally, we searched databases to identify studies reporting SF outcomes in patients with CCM\u2010related epilepsy who underwent ECoG\u2010guided surgery. A random\u2010effects model was used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventeen patients underwent ECoG\u2010tailored resection, and 50 underwent standard microsurgical lesionectomy (non\u2010ECoG). SF rates were higher in the ECoG group at 24\u2010, 30\u2010, and 36\u2010month follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05), although the ECoG group also displayed greater resection volumes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). After excluding temporal lobectomies, improved seizure outcomes remained significant only in extratemporal ECoG\u2010guided lesionectomies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). On univariate analysis, ECoG use and postsurgical antiseizure medication were significant predictors of SF. Meta\u2010analysis of seven studies, including our cohort, comprised 241 patients (130 ECoG, and 111 non\u2010ECoG) and demonstrated better seizure outcomes with ECoG\u2010guided resection compared to lesionectomy alone (OR\u2009=\u20096.01, 95% CI\u2009=\u20093.03\u201311.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>ECoG\u2010guided resection is associated with better long\u2010term SF in patients with CCM\u2010related epilepsy. Our evidence shows that ECoG may be a useful adjunct in cases of CCM\u2010related epilepsy surgery, particularly in extratemporal lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70378","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:36:08Z","timestamp":1783503368000},"page":"5165-5178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does electrocorticographic guidance improve seizure outcomes following cavernoma resection?"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9723-5573","authenticated-orcid":false,"given":"Aldo","family":"Barr\u00f3n\u2010Lomel\u00ed","sequence":"first","affiliation":[{"name":"Department of Neurosurgery National Institute of Neurology and Neurosurgery \u201cManuel Velasco Su\u00e1rez\u201d  Mexico City Mexico"},{"name":"Faculty of Medicine National Autonomous University of Mexico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1974-0321","authenticated-orcid":false,"given":"Brenda Susana","family":"Hern\u00e1ndez\u2010Barrera","sequence":"additional","affiliation":[{"name":"Autonomous University of San Luis Potosi  San Luis Potosi Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1833-9642","authenticated-orcid":false,"given":"Ana Margarita","family":"Mart\u00ednez\u2010C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Tamaulipas Institute of Higher Education and Science  Tamaulipas Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3561-4350","authenticated-orcid":false,"given":"Sharon Paola","family":"Garc\u00eda\u2010Trujillo","sequence":"additional","affiliation":[{"name":"University of the Valley of Mexico  Queretaro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5436-5900","authenticated-orcid":false,"given":"Zahira Elizabeth","family":"Medina\u2010F\u00e9lix","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery National Institute of Neurology and Neurosurgery \u201cManuel Velasco Su\u00e1rez\u201d  Mexico City Mexico"},{"name":"Autonomous University of Guadalajara  Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6685-5851","authenticated-orcid":false,"given":"Daniel","family":"San\u2010Juan","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic National Institute of Neurology and Neurosurgery \u201cManuel Velasco Su\u00e1rez\u201d  Mexico City 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