{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:57:33Z","timestamp":1785585453098,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015690","name":"South Carolina Clinical and Translational Research Institute, Medical University of South Carolina","doi-asserted-by":"publisher","award":["SCTR\u20102605"],"award-info":[{"award-number":["SCTR\u20102605"]}],"id":[{"id":"10.13039\/100015690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K02NS070960"],"award-info":[{"award-number":["K02NS070960"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS088748"],"award-info":[{"award-number":["R01NS088748"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32NS096050"],"award-info":[{"award-number":["T32NS096050"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Memory impairment is a common comorbidity in temporal lobe epilepsy (TLE) and is thought to arise from hippocampal dysfunction and disrupted interactions within a distributed memory network involving medial temporal, frontal, and parietal cortical regions. However, the network\u2010level mechanisms underlying memory impairment in TLE remain poorly understood. Leveraging complementary intracranial electroencephalography (iEEG) and resting\u2010state functional magnetic resonance imaging (rsfMRI), this study aimed to investigate hippocampal network alterations associated with memory dysfunction in TLE and characterize hippocampal\u2013cortical connectivity patterns linked to individual differences in memory performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 29 patients with TLE who underwent structural MRI and rsfMRI, 13 of whom also underwent interictal iEEG. For each participant, 94 subject\u2010specific regions of interest (ROIs) were generated, including 92 cortical ROIs from individualized rsfMRI parcellation and bilateral hippocampal ROIs defined using FreeSurfer subcortical segmentation. iEEG signals were projected onto these ROIs for cross\u2010modal alignment. Hippocampal\u2013cortical connectivity was estimated using rsfMRI functional connectivity and iEEG imaginary coherence, with hemispheres standardized relative to the epileptogenic side. Memory\u2010related connectivity within the hippocampal network was then identified through behavioral\u2013connectivity correlation analysis followed by Elastic Net regularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Increased ipsilesional hippocampal\u2013cortical alpha\u2010band (8\u201312\u2009Hz) connectivity derived from interictal iEEG was significantly correlated with worse Logical Memory performance. Consistently, rsfMRI analyses revealed a significant epileptogenic side (ipsilesional vs. contralesional) and connection type (within\u2010 vs. between\u2010hemisphere) interaction, with stronger within\u2010hemispheric hippocampal\u2013cortical connectivity in the ipsilesional hemisphere. Behavioral\u2013connectivity analyses indicate that immediate and delayed recall shared a core episodic memory architecture, but delayed recall relied more on large\u2010scale network coordination supporting retrieval after a delay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our multimodal findings suggest that increased hippocampal connectivity in the epileptogenic hemisphere may reflect pathological hypersynchronization that disrupts efficient memory network coordination in TLE and highlight hippocampal connectivity as a promising candidate biomarker for characterizing individual memory outcomes.<\/jats:p>\n                  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