{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:42:49Z","timestamp":1792226569450,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Calcitonin gene\u2010related peptide (CGRP) inhibitors modulate pain and neuroinflammation, a recognized contributor to epileptogenesis and status epilepticus (SE). We examined the association between CGRP inhibitor use and SE hospitalization in epilepsy patients with comorbid migraine. Using TriNetX (130 healthcare organizations), we identified patients with epilepsy from May 2018 through May 2026, and propensity\u2010matched cohorts for age, sex, race, anti\u2010seizure medications (ASMs), migraine diagnosis, migraine treatments, and cognitive impairment. The primary outcome was SE occurrence. Following matching, 17\u2009738 patients were on CGRP inhibitors and 18\u2009594 were not. SE occurred in 427 (2.41%) and 860 (4.63%) patients, respectively. Mean age (\u00b1SD) was 48.4\u2009\u00b1\u200914.9 vs 48.9\u2009\u00b1\u200917.0\u2009years. Risk difference was \u22122.2% (95% confidence interval [CI]: \u22122.6% to \u22121.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001), risk ratio 0.52 (95% CI: 0.46\u20130.58), and odds ratio 0.51 (95% CI: 0.45\u20130.57). SE\u2010related hospital visits were significantly fewer in the CGRP inhibitor group (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u2009\u22126.60,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). CGRP inhibitor use was associated with reduced SE occurrence and hospitalization, supporting further investigation in patients with comorbid migraine and epilepsy.\n                  <\/jats:p>","DOI":"10.1002\/epi.70436","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:51:09Z","timestamp":1786686669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Could calcitonin gene\u2010related peptide inhibitors prevent status epilepticus?"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-0077","authenticated-orcid":false,"given":"Michael","family":"Nsaka","sequence":"first","affiliation":[{"name":"Department of Neurology Milton S. Hershey Medical Center, Penn State College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Neurology and Centre for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), West German Headache Centre, University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Baban","sequence":"additional","affiliation":[{"name":"Drexel University College of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Allahdadian","sequence":"additional","affiliation":[{"name":"Department of Neurology Milton S. Hershey Medical Center, Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2266-7431","authenticated-orcid":false,"given":"Armin","family":"Scheffler","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), West German Headache Centre, University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), West German Headache Centre, University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-0384","authenticated-orcid":false,"given":"Dagny","family":"Holle","sequence":"additional","affiliation":[{"name":"Department of Neurology and Centre for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), West German Headache Centre, University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-5622","authenticated-orcid":false,"given":"Alain","family":"Lekoubou","sequence":"additional","affiliation":[{"name":"Department of Neurology Milton S. Hershey Medical Center, Penn State College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Public Health Sciences, A210 Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114152"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00580-x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69043-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00430-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1269241"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-023-01700-8"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215435109"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0940-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.116080"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1915327"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70266-6"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1649543"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.953224"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70348-9"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2011.02.012"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70436","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:27:33Z","timestamp":1792225653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/epi.70436"],"URL":"https:\/\/doi.org\/10.1002\/epi.70436","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"2026-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}