{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:16:43Z","timestamp":1787930203131,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to assess cenobamate (CNB) effectiveness, tolerability, and dosing in pediatric developmental and epileptic encephalopathies (DEEs), testing prespecified hypotheses on response by syndrome, etiology, electroencephalographic pattern, seizure type, CNB dose (mg\/kg\/day), and concomitant medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter cohort of children (\u226418\u2009years old) with DEEs were treated with CNB at 17 Spanish hospitals. Primary outcomes were retention, response (\u226550% reduction), and seizure freedom at 3, 6, and 12\u2009months. Mixed\u2010effects logistic and ordinal models were adjusted for age, syndrome, etiology, seizure type, and concomitant medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 152 children (median age\u2009=\u200912\u2009years), 27.6% had Lennox\u2013Gastaut syndrome (LGS) and 58.6% unspecified DEE, with a median of 9 prior antiseizure medications. Retention was 88%, 90%, and 93% and responder rates 64%, 73%, and 79% at 3, 6, and 12\u2009months; seizure freedom was 8%, 12%, and 18% (evaluable\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009152, 105, and 57 at 3, 6, and 12\u2009months, respectively). LGS and other DEEs reached identical 12\u2010month responder rates (both 79%), whereas Dravet syndrome showed limited sustained benefit. By etiology, structural cases had the highest 12\u2010month responder rate (93% vs. 68% in nonstructural,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04), but no etiology was independently associated with response. By seizure type, responder rates were highest for tonic (81%) and bilateral tonic\u2013clonic (76%) and lowest for absences (54%, adjusted odds ratio [OR] = .43,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.032). Treatment\u2010emergent seizure worsening occurred in 10.5%. Sodium channel blockers were the main risk factor for adverse events (OR\u2009=\u20092.10); 10.5% discontinued CNB due to adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>CNB was associated with sustained effectiveness and acceptable tolerability across pediatric DEEs. Slow weight\u2010based titration and proactive simplification of sodium channel blockers and clobazam may optimize benefit\u2013risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70460","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:17:59Z","timestamp":1787926679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric developmental epileptic encephalopathies treated with cenobamate: Real\u2010world outcomes across etiologies, syndromes, and seizure types"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-3365","authenticated-orcid":false,"given":"\u00c1ngel","family":"Aledo\u2010Serrano","sequence":"first","affiliation":[{"name":"Clinical Neurosciences Institute Blua Sanitas Valdebebas University Hospital  Madrid 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Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-5013","authenticated-orcid":false,"given":"Andrea","family":"Sariego Jamardo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6468-1939","authenticated-orcid":false,"given":"Gemma","family":"Aznar\u2010La\u00edn","sequence":"additional","affiliation":[{"name":"Consorci Mar Parc de Salut de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4582-6511","authenticated-orcid":false,"given":"Salvador","family":"Ib\u00e1\u00f1ez\u2010Mic\u00f3","sequence":"additional","affiliation":[{"name":"Hospital Virgen de la Arrixaca  Murcia 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