{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:18:22Z","timestamp":1788499102170,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["24779"],"award-info":[{"award-number":["24779"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023422","name":"Epilepsy Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["57840"],"award-info":[{"award-number":["57840"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In temporal lobe epilepsy (TLE), patients often present with neurobehavioral comorbidities encompassing affective and cognitive difficulties. Whereas the latter have been related to atypical connectivity of mesiotemporal and frontotemporal circuits, the brain basis of affective symptoms remains incompletely understood. Here, we assessed functional network substrates of affective symptoms and examined their relationship to structural magnetic resonance imaging (MRI), cognition, and clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 42 drug\u2010resistant patients who underwent multimodal 3\u2010T MRI as well as self\u2010report questionnaires of affective and cognitive functions outside the scanner, alongside 41 age\u2010 and sex\u2010matched healthy controls. Partial least squares (PLS), a brain\u2010wide multivariate associative technique, examined relationships between resting\u2010state functional MRI connectivity strength (FCS) and affective measures. Linear models assessed relationships with morphology and microstructure, as well as cognitive and clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Moderate to severe anxiety was present in 79% of patients, with concealing and adjustment as coping strategies, and 40% experienced depression. Quality of life scores were below published norm for epilepsy. PLS analysis revealed a latent component that accounted for 67% of the covariance between FCS and affective symptoms, linking weaker connectivity in temporoparietal and prefrontal cortices, as well as mesiotemporal, thalamic, and pallidal regions, to anxiety, low energy\/fatigue, medication\u2010related complaints, and reduced quality of life. Among cognitive domains, verbal memory positively correlated with the same brain areas. Cortices with the strongest covariance between FCS and affective variables presented with marked atrophy and myelin alterations (indexed by T1\/fluid\u2010attenuated inversion recovery decreases). Controlling for verbal memory and metrics of brain structure, the temporal\u2013parietal network remained the most compromised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Dysconnectivity of the temporal\u2013parietal network emerges as a key contributor to affective symptoms in TLE, and limbic network dysfunction additionally impacts cognition. These findings emphasize the importance of multidisciplinary care targeting both emotion regulation and stress reduction, alongside cognitive rehabilitation, for improved well\u2010being and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70470","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:45:30Z","timestamp":1788497130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain\u2010wide magnetic resonance imaging analysis of neurobehavioral comorbidities in temporal lobe epilepsy"],"prefix":"10.1002","author":[{"given":"Fatemeh","family":"Fadaie","sequence":"first","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital McGill University  Montreal Quebec 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1212\/CPJ.0000000000000874","article-title":"Psychiatric comorbidities in people with epilepsy","volume":"11","author":"Mula M","year":"2021","journal-title":"Neurol Clin Pract"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.775781","article-title":"Temporal lobe epilepsy and psychiatric comorbidity","volume":"12","author":"Vinti V","year":"2021","journal-title":"Front 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