{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:56:26Z","timestamp":1791464186025,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Recent work has provided population\u2010based estimates of the prevalence of cause\u2010specific epilepsy across the lifespan in Denmark. We sought to externally validate these Danish \u201csecondary epilepsy\u201d findings to ascertain consistency across geographic regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a population\u2010based cross\u2010sectional study using linked Alberta Health Care Insurance Plan administrative datasets. Epilepsy was identified using a validated algorithm. Point prevalence was calculated on December 31, 2018 among residents alive at that date. Secondary epilepsy was assigned when a recognized antecedent condition (stroke, traumatic brain injury [TBI], dementia, brain neoplasm, congenital brain malformations\/perinatal conditions, or central nervous system infection) occurred before the first epilepsy diagnosis. If no antecedent condition was identified, the case was classified as \u201cidiopathic.\u201d In sensitivity analyses, Danish\u2010derived definitions were replaced with published validated case definitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among ~4.274 million Albertans, 26\u2009056 prevalent epilepsy cases were identified (606 per 100\u2009000; 584 females, 628 males). Idiopathic epilepsy accounted for 394 per 100\u2009000 and secondary epilepsy for 212 per 100\u2009000. Prevalence peaked in childhood, stabilized by early adulthood, and then increased after age 40\u2009years, where male cases exceeded females. The proportional contribution of idiopathic epilepsy declined after midlife, with secondary epilepsy predominating by ages 65\u201370\u2009years. Cause\u2010specific patterns were largely consistent with Denmark, exhibiting age\u2010dependency: congenital\/perinatal causes in youth, TBI most common in young\/middle\u2010aged adults, and stroke and dementia in older adults. Use of published validated definitions reduced secondary epilepsy prevalence to 139 per 100\u2009000 and increased idiopathic prevalence to 467 per 100\u2009000, largely driven by fewer cases attributed to stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Secondary epilepsy becomes increasingly dominant with age, but cause\u2010specific attribution is sensitive to administrative case definitions. This highlights the need for rigorous and consistent algorithms to improve burden modeling, surveillance, and health\u2010system planning. These analyses validate the Danish estimates and inform future work deriving regional cause\u2010specific epilepsy burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70494","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:12:09Z","timestamp":1791461529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of epilepsy and the burden of underlying causes: Canadian validation of Danish estimates"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9653-5197","authenticated-orcid":false,"given":"Marin","family":"Anderson","sequence":"first","affiliation":[{"name":"Centre for Health Informatics University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-6435","authenticated-orcid":false,"given":"Jakob","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Neurology, Aarhus University Hospital affiliated member of EpiCARE  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Channa","family":"Buxbaum","sequence":"additional","affiliation":[{"name":"Institute for Health Metrics and Evaluation University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie","family":"Steinmetz","sequence":"additional","affiliation":[{"name":"Institute for Health Metrics and Evaluation University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Jette","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"O'Brien Institute for Public Health University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1061-9099","authenticated-orcid":false,"given":"Samuel","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"O'Brien Institute for Public Health University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-1651","authenticated-orcid":false,"given":"Colin B.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Centre for Health Informatics University of Calgary  Calgary Alberta Canada"},{"name":"Department of Clinical Neurosciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"O'Brien Institute for Public Health University of Calgary  Calgary Alberta 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