{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:08:46Z","timestamp":1790759326450,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Sleep deprivation (\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      ) triggers seizures in only a subset of patients with juvenile myoclonic epilepsy (\n                      <jats:styled-content style=\"fixed-case\">JME<\/jats:styled-content>\n                      ). We compared sleep macro\u2010architecture between\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      \u2010sensitive and\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      \u2010insensitive\n                      <jats:styled-content style=\"fixed-case\">JME<\/jats:styled-content>\n                      patients and healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Overnight polysomnography was done in healthy volunteers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930), JME patients without SD\u2010triggered seizures (SD\u2010insensitive,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931), and JME patients reporting SD\u2010triggered seizures on a structured interview (SD\u2010sensitive,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200968). Eleven participants with clinically diagnosed narcolepsy were excluded. We analyzed sleep continuity, stage distribution, rapid eye movement (REM)\/non\u2010REM (NREM) stability, and cardiorespiratory indices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SD\u2010insensitive patients had lower sleep efficiency than controls but preserved stage N3 and REM. SD\u2010sensitive patients had significantly lower N3 than SD\u2010insensitive patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002) and reduced REM vs controls (\n                      <jats:italic>q<\/jats:italic>\n                      \u2009=\u2009.005). SD\u2010sensitive status independently predicted N3% after adjusting for sex and anti\u2010seizure medication class (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22128.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.013), and remained significant after further adjustment for generalized tonic\u2013clonic seizure (GTCS) frequency (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22127.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.035). Valproate use was also independently associated with N3 reduction (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22128.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007). Respiratory and cardiac indices did not differ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>SD\u2010sensitive JME shows a light NREM\u2010dominant sleep profile with decreased N3 vs SD\u2010insensitive patients along with decreased REM when compared to controls. These differences are associative (SD sensitivity was self\u2010reported; no experimental challenge). No polysomnography parameter independently predicted SD sensitivity. Prospective studies with controlled SD challenge are required to determine if lighter sleep is a vulnerability factor or a parallel correlate of seizure risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70498","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:42:51Z","timestamp":1790757771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sleep macro\u2010architecture in sleep\u2010deprivation\u2013sensitive and sleep\u2010deprivation\u2013insensitive juvenile myoclonic epilepsy: A polysomnographic study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-3870","authenticated-orcid":false,"given":"Sujata","family":"Roshan","sequence":"first","affiliation":[{"name":"Department of Neurology Govind Ballabh Pant Institute of Medical Education and Research (GIPMER)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9680-4926","authenticated-orcid":false,"given":"Manvi","family":"Lamba","sequence":"additional","affiliation":[{"name":"Department of Neurology Maulana Azad Medical College  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2020.00045"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17236"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2001.0522"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.11.008"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.041137"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.06.021"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.08.009"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2024.05.014"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00911"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14171331"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.47936\/encephalitis.2024.00087"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1992.tb02322.x"},{"key":"e_1_2_13_14_1","volume-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, Version 2.6","author":"Berry 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