{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:05:29Z","timestamp":1789538729924,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Preclinical evidence supports the role of statins as antiepileptogenic agents. In this study, we investigated the risk of remote unprovoked seizures (RS) according to the use of statin therapy in a cohort of first\u2010ever status epilepticus (SE) survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis was made of adult patients (age\u2009\u2265\u200914\u2009years) with a first SE who were consecutively and prospectively admitted to the Modena Academic Hospital, Italy (September 2015\u2013December 2023) and included in the Modena Status Epilepticus Registry. Kaplan\u2013Meier survival analyses were used to calculate the probability of RS following the index SE event, whereas Cox proportional hazard and competing risk regression models were used to assess predictors of RS occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 314 patients were included (mean age\u2009=\u200970\u2009years, 63% females). The statin\u2010exposed cohort included both patients already receiving statins before SE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200968) and patients in whom statin administration was started during the hospitalization (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918). Atorvastatin (69\/86, 80%) was the most frequently prescribed statin. Overall, 67 patients (21.3%) developed RS (mean follow\u2010up\u2009=\u200931.5\u2009months). Cumulative probability of RS occurrence was 16%, 23%, and 32% at 12\u2009months, 2\u2009years, and 5\u2009years after SE, respectively. Median time from index event to first RS was 6.9\u2009months (interquartile range\u2009=\u200911.6\u2009months). Cumulative probability of RS was significantly lower in statin users compared to nonusers (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.038). After adjusting for confounders, the risk of RS was lower for those patients who used statins after the index event (hazard ratio = .48, 95% confidence interval [CI] = .26\u2013.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.023).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>The overall risk of RS was moderate and temporally confined within a few years from the index event. Statin exposure was associated with a lower incidence of RS. Our findings expand knowledge regarding a possible antiepileptogenic\u00a0role of statins after SE and support further studies in this field.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70503","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:43:47Z","timestamp":1789537427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Statin use and risk of remote seizure after first new onset status epilepticus"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-7363","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Orlandi","sequence":"first","affiliation":[{"name":"Neurophisiology Unit, Neuroscience Department Azienda Ospedaliera\u2010Universitaria  Modena Italy"},{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-5872","authenticated-orcid":false,"given":"Giada","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Neurophisiology Unit, Neuroscience Department Azienda Ospedaliera\u2010Universitaria  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6770-777X","authenticated-orcid":false,"given":"Lisa","family":"Taruffi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0981-4788","authenticated-orcid":false,"given":"Margherita","family":"Burani","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefe Laureine Ngnintedem","family":"Dontsop","sequence":"additional","affiliation":[{"name":"School of Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0577-5122","authenticated-orcid":false,"given":"Mara","family":"Malerba","sequence":"additional","affiliation":[{"name":"Neurophisiology Unit, Neuroscience Department Azienda Ospedaliera\u2010Universitaria  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Scolastico","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8090-7393","authenticated-orcid":false,"given":"Laura","family":"Madrassi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7653-9907","authenticated-orcid":false,"given":"Leonardo","family":"Affronte","sequence":"additional","affiliation":[{"name":"Neurophisiology Unit, Neuroscience Department Azienda Ospedaliera\u2010Universitaria  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3090-6247","authenticated-orcid":false,"given":"Matteo","family":"Pugnaghi","sequence":"additional","affiliation":[{"name":"Neurophisiology Unit, Neuroscience Department Azienda Ospedaliera\u2010Universitaria  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-7526","authenticated-orcid":false,"given":"Anna Elisabetta","family":"Vaudano","sequence":"additional","affiliation":[{"name":"Neurophisiology Unit, Neuroscience Department Azienda Ospedaliera\u2010Universitaria  Modena Italy"},{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-0083","authenticated-orcid":false,"given":"Simona","family":"Lattanzi","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Department of Experimental and Clinical Medicine Marche Polytechnic University  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-539X","authenticated-orcid":false,"given":"Stefano","family":"Meletti","sequence":"additional","affiliation":[{"name":"Neurophisiology Unit, Neuroscience Department Azienda Ospedaliera\u2010Universitaria  Modena Italy"},{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia  Modena Italy"},{"name":"Department of Medicine and Surgery University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/epi.14607","article-title":"Epidemiology of status epilepticus in adults: a population\u2010based study on incidence, causes, and outcomes","volume":"60","author":"Leitinger M","year":"2019","journal-title":"Epilepsia"},{"issue":"6","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1055\/s-0040-1718722","article-title":"Status epilepticus: definition, classification, pathophysiology, and epidemiology","volume":"40","author":"Johnson EL","year":"2020","journal-title":"Semin Neurol"},{"issue":"2","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/epi.14515","article-title":"Long\u2010term outcomes of status epilepticus: a critical assessment","volume":"59","author":"Sculier C","year":"2018","journal-title":"Epilepsia"},{"issue":"1","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1528-1157.1997.tb01083.x","article-title":"Functional anatomy of spontaneous seizures in a rat model of limbic epilepsy","volume":"38","author":"Bertram EH","year":"1997","journal-title":"Epilepsia"},{"issue":"2","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0920-1211(99)00088-1","article-title":"A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat","volume":"38","author":"Nissinen J","year":"2000","journal-title":"Epilepsy Res"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1212\/01.wnl.0000265056.31752.ff","article-title":"Recurrence of afebrile status epilepticus in a population\u2010based study in Rochester, Minnesota","volume":"69","author":"Hesdorffer DC","year":"2007","journal-title":"Neurology"},{"issue":"3","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/epi.12903","article-title":"Recurrence of status epilepticus: prognostic role and outcome predictors","volume":"56","author":"Tsetsou S","year":"2015","journal-title":"Epilepsia"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.seizure.2022.02.012","article-title":"Recurrent status epilepticus: clinical features and recurrence risk in an adult population","volume":"97","author":"Orlandi N","year":"2022","journal-title":"Seizure"},{"issue":"3","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1212\/WNL.50.3.735","article-title":"Incidence of status epilepticus in Rochester, Minnesota, 1965\u20131984","volume":"50","author":"Hesdorffer DC","year":"1998","journal-title":"Neurology"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yebeh.2015.04.059","article-title":"Prognosis of status epilepticus (SE): relationship between SE duration and subsequent development of epilepsy","volume":"49","author":"Santamarina E","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"9","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1111\/epi.17697","article-title":"Prediction of long\u2010term unprovoked seizures after status epilepticus","volume":"64","author":"Rodrigo\u2010Gisbert M","year":"2023","journal-title":"Epilepsia"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.110109","article-title":"Drug repurposing in status epilepticus","volume":"161","author":"Walker MC","year":"2024","journal-title":"Epilepsy Behav"},{"issue":"1","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach F","year":"2020","journal-title":"Eur Heart J"},{"issue":"4","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1582-4934.2001.tb00172.x","article-title":"Statins: mechanism of action and effects","volume":"5","author":"Stancu C","year":"2001","journal-title":"J Cell Mol Med"},{"issue":"1","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-024-01025-0","article-title":"The pleiotropic effects of statins: a comprehensive exploration of neurovascular unit modulation and blood\u2010brain barrier protection","volume":"30","author":"Liu JC","year":"2024","journal-title":"Mol Med"},{"issue":"8","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1111\/epi.17303","article-title":"Statins as antiepileptogenic drugs: analyzing the evidence and identifying the most promising statin","volume":"63","author":"Hufthy Y","year":"2022","journal-title":"Epilepsia"},{"issue":"10","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1111\/epi.17753","article-title":"Acute symptomatic status epilepticus: splitting or lumping? A proposal of classification based on real\u2010world data","volume":"64","author":"Lattanzi S","year":"2023","journal-title":"Epilepsia"},{"issue":"4","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/epi.17912","article-title":"The risk of unprovoked seizure occurrence after status epilepticus in adults","volume":"65","author":"Lattanzi S","year":"2024","journal-title":"Epilepsia"},{"issue":"4","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16177","article-title":"Remote seizures and drug\u2010resistant epilepsy after a first status epilepticus in adults","volume":"31","author":"Orlandi N","year":"2024","journal-title":"Eur J Neurol"},{"issue":"2","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/epi4.12383","article-title":"Clinical outcomes and treatments effectiveness in status epilepticus resolved by antiepileptic drugs: a five\u2010year observational study","volume":"5","author":"Orlandi N","year":"2020","journal-title":"Epilepsia Open"},{"issue":"4","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13040936","article-title":"The role of early intubation in status epilepticus with out\u2010of\u2010hospital onset: a large prospective observational study","volume":"13","author":"Turcato G","year":"2024","journal-title":"J Clin Med"},{"issue":"16","key":"e_1_2_12_23_1","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1681483","article-title":"Benzodiazepines versus non\u2010benzodiazepine antiseizure medications as first\u2010line agents for status epilepticus: analysis of real word data from a 9\u2010years prospective cohort","volume":"12","author":"Brigo F","year":"2025","journal-title":"Front Neurol"},{"key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yebeh.2015.04.022","article-title":"Use of an online epilepsy diary to characterize repetitive seizures","volume":"47","author":"Fisher RS","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"10","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus\u2010\u2010report of the ILAE task force on classification of status epilepticus","volume":"56","author":"Trinka E","year":"2015","journal-title":"Epilepsia"},{"key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.yebeh.2015.05.007","article-title":"Salzburg consensus criteria for non\u2010convulsive status epilepticus\u2010\u2010approach to clinical application","volume":"49","author":"Leitinger M","year":"2015","journal-title":"Epilepsy Behav"},{"issue":"1","key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WNP.0000000000000806","article-title":"American clinical neurophysiology Society's standardized critical care EEG terminology: 2021 version","volume":"38","author":"Hirsch LJ","year":"2021","journal-title":"J Clin Neurophysiol"},{"issue":"10","key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1093\/brain\/awr215","article-title":"The treatment of super\u2010refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol","volume":"134","author":"Shorvon S","year":"2011","journal-title":"Brain"},{"issue":"4","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1528-1167.2009.02285.x","article-title":"Recommendation for a definition of acute symptomatic seizure","volume":"51","author":"Beghi E","year":"2010","journal-title":"Epilepsia"},{"issue":"9596","key":"e_1_2_12_30_1","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"Elm E","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pneurobio.2009.02.002","article-title":"Statins: mechanisms of neuroprotection","volume":"88","author":"Most PJ","year":"2009","journal-title":"Prog Neurobiol"},{"issue":"3","key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neulet.2008.05.112","article-title":"Statin inhibits kainic acid\u2010induced seizure and associated inflammation and hippocampal cell death","volume":"440","author":"Lee JK","year":"2008","journal-title":"Neurosci Lett"},{"issue":"1","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yebeh.2010.10.001","article-title":"Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long\u2010lasting status epilepticus","volume":"20","author":"Gouveia TL","year":"2011","journal-title":"Epilepsy Behav"},{"issue":"11","key":"e_1_2_12_34_1","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/j.1528-1167.2011.03261.x","article-title":"Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol\u2010induced seizures","volume":"52","author":"Funck VR","year":"2011","journal-title":"Epilepsia"},{"issue":"8","key":"e_1_2_12_35_1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/epi.12686","article-title":"Protective effects of some statins on epileptogenesis and depressive\u2010like behavior in WAG\/Rij rats, a genetic animal model of absence epilepsy","volume":"55","author":"Citraro R","year":"2014","journal-title":"Epilepsia"},{"issue":"2","key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.pharep.2017.08.016","article-title":"Subtle improvement of seizure susceptibility by atorvastatin treatment during epileptogenesis","volume":"70","author":"Oliveira CV","year":"2018","journal-title":"Pharmacol Rep"},{"key":"e_1_2_12_37_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2023.109133","article-title":"Repurposing of cholesterol\u2010lowering agents in 429 status epilepticus: a neuroprotective effect of simvastatin","volume":"141","author":"Hanin A","year":"2023","journal-title":"Epilepsy Behav"},{"issue":"17","key":"e_1_2_12_38_1","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1212\/WNL.0b013e3181f96253","article-title":"Statin use and risk of epilepsy: a nested case\u2010control study","volume":"75","author":"Etminan M","year":"2010","journal-title":"Neurology"},{"key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jocn.2020.11.023","article-title":"Statin on post\u2010stroke epilepsy: a systematic review and meta\u2010analysis","volume":"83","author":"Fang J","year":"2021","journal-title":"J Clin Neurosci"},{"issue":"2","key":"e_1_2_12_40_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/epi4.70008","article-title":"Statins' protective effects on focal epilepsy are independent of LDL\u2010C","volume":"10","author":"Sun Z","year":"2025","journal-title":"Epilepsia Open"},{"issue":"2","key":"e_1_2_12_41_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/ene.12428","article-title":"Statins are associated with decreased mortality risk after status epilepticus","volume":"22","author":"Sierra\u2010Marcos A","year":"2015","journal-title":"Eur J Neurol"},{"issue":"2","key":"e_1_2_12_42_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/aje\/kwp107","article-title":"Competing risk regression models for epidemiologic data","volume":"170","author":"Lau B","year":"2009","journal-title":"Am J Epidemiol"},{"issue":"6","key":"e_1_2_12_43_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/ana.410440609","article-title":"Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus","volume":"44","author":"Hesdorffer DC","year":"1998","journal-title":"Ann Neurol"},{"issue":"2","key":"e_1_2_12_44_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1474-4422(17)30404-0","article-title":"Prediction of late seizures after ischaemic stroke with a novel prognostic model (the SeLECT score): a multivariable prediction model development and validation study","volume":"17","author":"Galovic M","year":"2018","journal-title":"Lancet Neurol"},{"issue":"11","key":"e_1_2_12_45_1","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1111\/epi.18114","article-title":"Prediction of epilepsy after stroke: proposal of a modified SeLECT 2.0 score based on posttreatment stroke outcome","volume":"65","author":"Meletti S","year":"2024","journal-title":"Epilepsia"},{"issue":"7","key":"e_1_2_12_46_1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1161\/STROKEAHA.124.050045","article-title":"Association of the Timing and Type of acute symptomatic seizures with Poststroke epilepsy and mortality","volume":"56","author":"Schubert KM","year":"2025","journal-title":"Stroke"},{"issue":"4","key":"e_1_2_12_47_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher RS","year":"2014","journal-title":"Epilepsia"},{"issue":"11","key":"e_1_2_12_48_1","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2023.1251914","article-title":"Neuroinflammation and status epilepticus: a narrative review unraveling a complex interplay","volume":"21","author":"Foiadelli T","year":"2023","journal-title":"Front Pediatr"},{"issue":"2","key":"e_1_2_12_49_1","doi-asserted-by":"crossref","DOI":"10.5662\/wjm.v15.i2.99580","article-title":"Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy","volume":"15","author":"Tayal V","year":"2025","journal-title":"World J Methodol"},{"issue":"7","key":"e_1_2_12_50_1","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000214774","article-title":"Peri\u2010ictal MRI abnormalities and risk of unprovoked seizures after De novo status epilepticus","volume":"106","author":"Orav K","year":"2026","journal-title":"Neurology"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70503","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:43:53Z","timestamp":1789537433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":49,"alternative-id":["10.1002\/epi.70503"],"URL":"https:\/\/doi.org\/10.1002\/epi.70503","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"2026-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"epi.70503"}}