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The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden unexpected death in epilepsy. Most preclinical therapeutic strategies aim to enhance endogenous\n                      <jats:italic>Scn1a<\/jats:italic>\n                      gene expression or deliver a functional copy via perinatal interventions. Although promising, these approaches face challenges in achieving efficient brain\u2010wide delivery, targeting all interested brain areas.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, we used a conditional DS reversible mouse model (\n                      <jats:italic>Scn1a<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>Stop\/+<\/jats:italic>\n                      <\/jats:sup>\n                      ) to assess the therapeutic potential of postsymptomatic restoration (postnatal day 30) of Na\n                      <jats:sub>V<\/jats:sub>\n                      1.1 physiological levels in all neuronal populations but restricted to minimal brain regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that hippocampal correction alone reduces seizure susceptibility, whereas simultaneous restoration in the hippocampus, thalamus, and overlying somatosensory and visual cortex was associated with a trend toward further reduction in seizure burden and improved survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>These findings indicate that hippocampal restoration accounts for a substantial component of the therapeutic benefit, and broader network correction may confer additional advantages.<\/jats:p>\n                  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