{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:55:32Z","timestamp":1790873732828,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI 969\u2010B"],"award-info":[{"award-number":["KLI 969\u2010B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether non\u2010contrast pseudo\u2010continuous arterial spin labeling (pCASL) detects status epilepticus (SE)\u2013related perfusion abnormalities and shows quantitative correspondence with dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging (MRI), and to compare single\u2010slice and volumetric approaches for asymmetry assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients from a prospectively recruited single\u2010center SE cohort were included in this retrospective analysis when MRI was performed within 48\u2009h after clinical SE onset and both pCASL and DSC perfusion sequences were available. Visual assessment was pCASL\u2010led, with corresponding DSC\u2010derived cerebral blood flow (CBF) and cerebral blood volume (CBV) maps subsequently evaluated. Perfusion asymmetry was quantified using mirrored contralateral reference regions. Single\u2010slice peak\u2010abnormality and volumetric segmentation approaches were applied to pCASL, DSC\u2010derived cerebral blood flow (CBF), and cerebral blood volume (CBV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 982 individuals with SE, 180 underwent MRI including pCASL and DSC within 48\u2009h. pCASL\u2010led assessment identified SE\u2010related perfusion abnormalities in 75 of 180 (42%): hyperperfusion in 65, hypoperfusion in 6, and pCASL\u2013DSC discordance in 4. Corresponding DSC abnormalities were present in 71 of 75 (95%). Thus, quantitative asymmetry analysis was performed in 71 unilateral evaluable cases. In the hyperperfusion subgroup, pCASL asymmetry correlated significantly with DSC\u2010derived CBF using both volumetric and single\u2010slice assessment (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009.558 and\n                      <jats:italic>\u03c1\u2009=<\/jats:italic>\n                      \u2009.571, respectively; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), and with DSC\u2010derived CBV (\n                      <jats:italic>\u03c1\u2009=<\/jats:italic>\n                      \u2009.495 and\n                      <jats:italic>\u03c1\u2009=<\/jats:italic>\n                      \u2009.374, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003). Single\u2010slice and volumetric pCASL asymmetry showed strong correspondence (\n                      <jats:italic>\u03c1\u2009=<\/jats:italic>\n                      \u2009.773,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). No significant difference was observed between single\u2010slice and volumetric pCASL asymmetry after correction for multiple comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Non\u2010contrast pCASL detected SE\u2010related peri\u2010ictal perfusion abnormalities and showed significant quantitative correspondence with DSC\u2010derived CBF and CBV in parenchymal hyperperfusion. Single\u2010slice pCASL asymmetry showed strong agreement with volumetric assessment, supporting its use as a pragmatic approach for clinically oriented evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70518","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:59:03Z","timestamp":1790870343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010contrast\n                    <scp>MRI<\/scp>\n                    reliably captures perfusion abnormalities in status epilepticus"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-8992","authenticated-orcid":false,"given":"Lukas","family":"Machegger","sequence":"first","affiliation":[{"name":"Department of Neuroradiology Christian Doppler University Hospital, Paracelsus Medical University  Salzburg Austria"},{"name":"Institute of Visual Computing &amp; Human\u2010Centered Technology, Faculty of Informatics TU Wien  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-7863","authenticated-orcid":false,"given":"Pilar","family":"Bosque\u2010Varela","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Member of the European Reference Network EpiCARE Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-8226","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Steinbacher","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Christian Doppler University Hospital, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0672-5718","authenticated-orcid":false,"given":"Johannes","family":"Pfaff","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Christian Doppler University Hospital, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-2692","authenticated-orcid":false,"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Member of the European Reference Network EpiCARE Paracelsus Medical University  Salzburg Austria"},{"name":"Neuroscience Institute Christian Doppler University Hospital, Centre for Cognitive Neuroscience  Salzburg Austria"},{"name":"Karl Landsteiner Institute for Clinical Neuroscience  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-8506","authenticated-orcid":false,"given":"Giorgi","family":"Kuchukhidze","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Member of the European Reference Network EpiCARE Paracelsus Medical University  Salzburg Austria"},{"name":"Neuroscience Institute Christian Doppler University Hospital, Centre for Cognitive Neuroscience  Salzburg Austria"},{"name":"Karl Landsteiner Institute for Clinical Neuroscience  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000001103"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14499"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17359"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18604"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.02.003"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17949"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17404"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013\u20109580.2004.04014.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2013.03.023"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2026.05.002"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.220088"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.10.009"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.12.008"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4341"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201003698\u20107"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010014\u20100080\u2010y"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12270"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000806"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/jnrp.jnrp_141_17"},{"key":"e_1_2_13_22_1","unstructured":"KoflerF 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