{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:50:15Z","timestamp":1791283815174,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to present more than 2 decades of experience with stereoelectroencephalography (SEEG)\u2010guided radiofrequency thermocoagulation (RF\u2010TC) in focal drug\u2010resistant epilepsy and to identify clinical, electrophysiological, and procedural predictors of treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied 244 consecutive patients treated with SEEG\u2010guided RF\u2010TC at our center between 2001 and 2024. All had at least 2 months of follow\u2010up, and 240 (98.4%) completed 1 year. Outcomes were assessed at 2, 6, and 12\u2009months. The primary endpoint was seizure freedom at 2 months and 1 year without additional surgery, and the secondary endpoint was \u226550% seizure reduction. Demographic and epilepsy\u2010, imaging\u2010, and procedure\u2010related variables were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 2 months, 160 patients (65.6%) were responders, including 63 (25.8%) seizure\u2010free. At 1 year, among 135 patients treated exclusively with SEEG\u2010guided RF\u2010TC, 64 (51.2%) were responders, including 19 (14.1%) seizure\u2010free. At 5\u2009years, 6.1% treated exclusively with SEEG\u2010guided RF\u2010TC remained seizure\u2010free. Magnetic resonance imaging was negative in 40.6%, and focal cortical dysplasia was the most frequent imaging finding (20.1%). A higher number of contacts was associated with lower seizure\u2010free rates at 1 year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.046). Pathology and electrode number were the only variables associated with 1\u2010year outcomes. The positive predictive value of being a responder at 2 months for favorable surgical outcome was 83%, and the negative predictive value was 44%. Recoagulation within the first year was strongly associated with clinical improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00001). Neurological complications occurred in 2.9%, including .8% permanent deficits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>SEEG\u2010guided RF\u2010TC is a safe diagnostic option with some therapeutic implication (6% seizure freedom in 5\u2009years) for selected patients with drug\u2010resistant focal epilepsy. Early response predicts favorable long\u2010term outcomes, and repeated coagulation can enhance clinical results. Pathology and the number of contacts used in thermocoagulation may serve as potential prognostic factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70524","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:50:16Z","timestamp":1791280216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stereoelectroencephalography\u2010guided radiofrequency thermocoagulation in drug\u2010resistant focal epilepsy: Results from more than 20\u2009years of experience"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9044-5481","authenticated-orcid":false,"given":"Francisco","family":"Spessatto Pesente","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-099X","authenticated-orcid":false,"given":"Milena Gerke","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Functional Neurology and Epileptology Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-8521","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Catenoix","sequence":"additional","affiliation":[{"name":"Department of Functional Neurology and Epileptology Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4768-290X","authenticated-orcid":false,"given":"David","family":"Morizet","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1795-471X","authenticated-orcid":false,"given":"Alexandra","family":"Montavont","sequence":"additional","affiliation":[{"name":"Department of Functional Neurology and Epileptology Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"},{"name":"Department of Pediatric Clinical Neurophysiology Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-8515","authenticated-orcid":false,"given":"Sylvain","family":"Rheims","sequence":"additional","affiliation":[{"name":"Department of Pediatric Clinical Neurophysiology Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"},{"name":"Lyon University, Claude Bernard University  Lyon France"},{"name":"Neuroscience Research Center of Lyon, French National Institute of Health and Medical Research (Inserm U1028)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6929-9273","authenticated-orcid":false,"given":"Karine","family":"Ostrowsky\u2010Coste","sequence":"additional","affiliation":[{"name":"Department of Pediatric Clinical Neurophysiology Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-4887","authenticated-orcid":false,"given":"Claire","family":"Haegelen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"},{"name":"Lyon University, Claude Bernard University  Lyon France"},{"name":"Neuroscience Research Center of Lyon, French National Institute of Health and Medical Research (Inserm U1028)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-2138","authenticated-orcid":false,"given":"Marc","family":"Guenot","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospices Civils de Lyon (Lyon University Hospital), Hospital for Neurology and Neurosurgery Pierre Wertheimer  Lyon France"},{"name":"Lyon University, Claude Bernard University  Lyon France"},{"name":"Neuroscience Research Center of Lyon, French National Institute of Health and Medical Research (Inserm U1028)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Textbook of stereotactic and functional neurosurgery","author":"Benabid AL","year":"2009"},{"key":"e_1_2_11_3_1","first-page":"315","article-title":"Methodology of stereo EEG exploration and surgical intervention in epilepsy","volume":"45","author":"Bancaud J","year":"1973","journal-title":"Rev Otoneuroophtalmol"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"242","article-title":"Clinical application of radiofrequency ablation technology","volume":"19","author":"Li YZ","year":"2010","journal-title":"J Intervent Radiol"},{"issue":"1","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12940-021-00768-1","article-title":"Development of 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Indications, results, complications and therapeutic applications in a series of 100 consecutive cases","volume":"77","author":"Guenot M","year":"2001","journal-title":"Stereotact Funct Neurosurg"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.wneu.2016.06.095","article-title":"Stereo\u2010electro\u2010encephalography\u2010guided radiofrequency thermocoagulation: from in\u00a0vitro and in\u00a0vivo data to technical guidelines","volume":"94","author":"Bourdillon P","year":"2016","journal-title":"World Neurosurg"},{"issue":"1","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neucli.2017.11.005","article-title":"French guidelines on stereoelectroencephalography (SEEG)","volume":"48","author":"Isnard J","year":"2018","journal-title":"Neurophysiol Clin"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-7091-0179-7_4","article-title":"SEEG\u2010guided RF\u2010thermocoagulation of epileptic foci: a therapeutic alternative for drug\u2010resistant non\u2010operable partial epilepsies","volume":"36","author":"Guenot M","year":"2011","journal-title":"Adv Tech Stand Neurosurg"},{"issue":"8","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/brain\/123.8.1733","article-title":"Stereoelectroencephalography in focal cortical dysplasia: a 3D approach to delineating the dysplastic cortex","volume":"123","author":"Chassoux F","year":"2000","journal-title":"Brain"},{"issue":"8","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1212\/WNL.43.8.1612","article-title":"Update on surgical treatment of the epilepsies. Summary of the second international Palm Desert conference on the surgical treatment of the epilepsies (1992)","volume":"43","author":"Engel J","year":"1993","journal-title":"Neurology"},{"issue":"2","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci14020110","article-title":"Stereoelectroencephalography\u2010guided radiofrequency thermocoagulation: diagnostic and therapeutic implications","volume":"14","author":"Castellano JF","year":"2024","journal-title":"Brain Sci"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.wneu.2020.07.194","article-title":"Surgical outcomes of laser interstitial thermal therapy for temporal lobe epilepsy: systematicreview and meta\u2010analysis","volume":"143","author":"Kerezoudis P","year":"2020","journal-title":"World Neurosurg"},{"issue":"3","key":"e_1_2_11_16_1","first-page":"441","article-title":"Multiple SEEG\u2010guided RF\u2010thermolesions of epileptogenic 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