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Together with previously reported cases, these observations raise the possibility that skeletal fragility may represent an underrecognized feature of the clinical spectrum associated with pathogenic\n                    <jats:italic>SCN8A<\/jats:italic>\n                    variants. Experimental and clinical findings provide biological plausibility for altered bone remodeling, while the marked reduction in fracture burden following pamidronate therapy underscores the importance of early recognition and management of skeletal complications in this population.\n                  <\/jats:p>","DOI":"10.1002\/epi.70544","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:02:01Z","timestamp":1791648121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe skeletal fragility in\n                    <scp>\n                      <i>SCN8A<\/i>\n                    <\/scp>\n                    \u2010related developmental and epileptic encephalopathy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5303-5528","authenticated-orcid":false,"given":"Ad\u00e9lia Maria","family":"de Miranda 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