{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:40:22Z","timestamp":1792471222889,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371951"],"award-info":[{"award-number":["82371951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32541017"],"award-info":[{"award-number":["32541017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0701703"],"award-info":[{"award-number":["2018YFA0701703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to elucidate the neuroanatomical and network substrates underlying diverse seizure symptoms in mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE\u2010HS) by applying multivariate support vector regression (SVR) to individualized structural symptom mapping and atrophy network mapping (ANM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively enrolled 216 patients with mTLE\u2010HS and 460 healthy controls. Six non\u2010mutually exclusive seizure symptoms were assessed. We performed left\u2013right flipping of all images of right\u2010sided mTLE\u2010HS patients along the midline before processing the data. Individual atrophy gray matter maps were derived using normative modeling. Structural symptom mapping was performed using multivariate SVR lesion\u2013symptom mapping. For each patient, indirect ANM maps were generated using a normative functional connectome and direct ANM maps using the patient's own resting\u2010state functional magnetic resonance imaging. Correspondence between the two ANM approaches was assessed using individual\u2010level whole\u2010brain spatial correlations of unthresholded maps and group\u2010level Dice coefficients of thresholded maps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Individual structural atrophy patterns were spatially heterogeneous, whereas different seizure manifestations were associated with partially distinct structural patterns and more spatially convergent network\u2010level associations. Focal to bilateral tonic\u2013clonic seizures were associated with thalamic network involvement, gestural\/limb automatisms with anterior cingulate\u2010related networks, ictal vocalization symptoms with perisylvian language networks, dysmnesia with hippocampal\u2013posteromedial networks, emotional phenomena with prefrontal\u2013temporal networks, and autonomic phenomena with medial prefrontal and limbic networks. Furthermore, limited spatial correspondence was observed between the results of the direct and indirect atrophy network analyses, suggesting the indirect and direct ANM can be regarded as nonequivalent but potentially complementary approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>In mTLE\u2010HS, heterogeneous seizure manifestations are associated with distinct patterns of atrophy and distributed functional network involvement. ANM provides a complementary framework for characterizing symptom\u2010related network patterns, and differences between indirect\/normative and direct\/patient\u2010specific connectome analyses may provide complementary information.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70545","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:22:19Z","timestamp":1792470139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptom\u2010related damage patterns in mesial temporal lobe epilepsy with hippocampal sclerosis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9141-392X","authenticated-orcid":false,"given":"Zhaojie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-7515","authenticated-orcid":false,"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9606-7958","authenticated-orcid":false,"given":"Keran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-9336","authenticated-orcid":false,"given":"Qirui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"},{"name":"Farber Institute for Neuroscience, Department of Neurology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2647-3898","authenticated-orcid":false,"given":"Yuzhuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-6420","authenticated-orcid":false,"given":"Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-7193","authenticated-orcid":false,"given":"Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-8102","authenticated-orcid":false,"given":"Jianrui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5060-8914","authenticated-orcid":false,"given":"Yiwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical 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Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-2314","authenticated-orcid":false,"given":"Guangming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-7330","authenticated-orcid":false,"given":"Zhiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S1474-4422(21)00023-5","article-title":"Epilepsy in China: major 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