{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:16:58Z","timestamp":1773119818390,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["671055"],"award-info":[{"award-number":["671055"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M025489\/1"],"award-info":[{"award-number":["MR\/M025489\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A high prevalence of epilepsy is reported in many onchocerciasis\u2010endemic regions. In this paper we discuss recent epidemiological and clinical aspects as well as public health implications of onchocerciasis\u2010associated epilepsy (<jats:styled-content style=\"fixed-case\">OAE<\/jats:styled-content>) and propose a strategy to reduce the burden of disease. <jats:styled-content style=\"fixed-case\">OAE<\/jats:styled-content> probably presents in a variety of clinical manifestations, including the nodding syndrome and the Nakalanga syndrome. The most common clinical presentation, however, is generalized (primarily tonic\u2010clonic) seizures. A characteristic of <jats:styled-content style=\"fixed-case\">OAE<\/jats:styled-content> is the onset of seizures between the ages of 3 and 18 years and clustering in certain families and villages close to rapid\u2010flowing black\u2010fly\u2010infested rivers. A strategy combining active surveillance for epilepsy with early treatment with antiepileptic drugs and prevention of onchocerciasis by increasing the geographical and therapeutic coverage of community\u2010directed treatment with ivermectin (<jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content>i) may considerably decrease the burden of disease.<\/jats:p>","DOI":"10.1002\/epi4.12054","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T10:21:03Z","timestamp":1490437263000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Onchocerciasis\u2010associated epilepsy: From recent epidemiological and clinical findings to policy implications"],"prefix":"10.1002","volume":"2","author":[{"given":"Robert","family":"Colebunders","sequence":"first","affiliation":[{"name":"Global Health Institute University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred K.","family":"Njamnshi","sequence":"additional","affiliation":[{"name":"Neurology Department Central Hospital Yaound\u00e9 Faculty of Medicine and Biomedical Sciences the University of Yaound\u00e9 I Yaound\u00e9 I Republic of Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke","family":"van Oijen","sequence":"additional","affiliation":[{"name":"Global Health Institute University of Antwerp Antwerp Belgium"},{"name":"Department of Neurology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deby","family":"Mukendi","sequence":"additional","affiliation":[{"name":"Neuro\u2010psycho\u2010pathological Centre University of Kinshasa Kinshasa Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marie","family":"Kashama","sequence":"additional","affiliation":[{"name":"Neuro\u2010psycho\u2010pathological Centre University of Kinshasa Kinshasa Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Mandro","sequence":"additional","affiliation":[{"name":"Provincial division of Health of Ituri Ministery of Health Bunia Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolbert","family":"Gumisiriza","sequence":"additional","affiliation":[{"name":"Busitema University Mbale Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Marie","family":"Preux","sequence":"additional","affiliation":[{"name":"Tropical Neuro\u2010epidemiology unit University of Limoge Limoges France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Suykerbuyk","sequence":"additional","affiliation":[{"name":"Global Health Institute University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Idro","sequence":"additional","affiliation":[{"name":"College of Health Sciences Makerere University Kampala Uganda"},{"name":"Nuffield Department of Medicine Centre for Tropical Medicine and Global Health University of Oxford Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822cfc90"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.02.020405"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70003-6"},{"key":"e_1_2_11_5_1","unstructured":"World Health Organization.Investing to overcome the global impact of neglected tropical diseases. 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