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Approximately 64% of the patients have structural, metabolic, genetic, or infectious etiologies and, in the rest, the etiology is unknown. Here we review the contribution of etiologies due to various metabolic disorders in the pathology of<jats:styled-content style=\"fixed-case\">WS<\/jats:styled-content>. These may include metabolic errors in organic molecules involved in amino acid and glucose metabolism, fatty acid oxidation, metal metabolism, pyridoxine deficiency or dependency, or acidurias in organelles such as mitochondria and lysosomes. We discuss the biochemical, clinical, and<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>features of these disorders as well as the evidence of how they may be implicated in the pathogenesis and treatment of<jats:styled-content style=\"fixed-case\">WS<\/jats:styled-content>. The early recognition of these etiologies in some cases may permit early interventions that may improve the course of the disease.<\/jats:p>","DOI":"10.1002\/epi4.12102","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T17:09:45Z","timestamp":1517332185000},"page":"134-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Metabolic etiologies in West syndrome"],"prefix":"10.1002","volume":"3","author":[{"given":"Seda","family":"Salar","sequence":"first","affiliation":[{"name":"Laboratory of Developmental Epilepsy Saul R. Korey Department of Neurology Montefiore\/Einstein Epilepsy Center Albert Einstein College of Medicine Bronx New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon L.","family":"Mosh\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Epilepsy Saul R. 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