{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:17:06Z","timestamp":1774415826027,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["13\/CDA\/2223"],"award-info":[{"award-number":["13\/CDA\/2223"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["16\/RC\/3948"],"award-info":[{"award-number":["16\/RC\/3948"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["279062 \"EpiPGX\""],"award-info":[{"award-number":["279062 \"EpiPGX\""]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","award":["418\u20100\u20100"],"award-info":[{"award-number":["418\u20100\u20100"]}],"id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real\u2010world clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested the association of clinical predictors with treatment response using regression modeling in a cohort of people with refractory epilepsy. Genetic assessment for lacosamide response was conducted via genome\u2010wide association studies and exome studies, comprising 281 candidate genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients (479\/483) were treated with LCM in addition to other AEDs. Our results corroborate previous findings that patients with refractory genetic generalized epilepsy (GGE) may respond to treatment with LCM. No clear clinical predictors were identified. We then compared 73 lacosamide responders, defined as those experiencing greater than 75% seizure reduction or seizure freedom, to 495 nonresponders (&lt;25% seizure reduction). No variants reached the genome\u2010wide significance threshold in our case\u2010control analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>No genetic predictor of lacosamide response was identified. Patients with refractory GGE might benefit from treatment with lacosamide.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12360","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T01:29:16Z","timestamp":1568251756000},"page":"563-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genomic and clinical predictors of lacosamide response in refractory epilepsies"],"prefix":"10.1002","volume":"4","author":[{"given":"Sin\u00e9ad B.","family":"Heavin","sequence":"first","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences Royal College of Surgeons Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8213-6141","authenticated-orcid":false,"given":"Mark","family":"McCormack","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences Royal College of Surgeons Dublin Ireland"},{"name":"Luxembourg Centre for Systems Biomedicine University of Luxembourg Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1460-6623","authenticated-orcid":false,"given":"Stefan","family":"Wolking","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Slattery","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences Royal College of Surgeons Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Walley","sequence":"additional","affiliation":[{"name":"Centre for Human Genome Variation Duke University Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreja","family":"Avbersek","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK"},{"name":"Chalfont Centre for Epilepsy Buckinghamshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-7083","authenticated-orcid":false,"given":"Jan","family":"Novy","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK"},{"name":"Chalfont Centre for Epilepsy Buckinghamshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurabh R.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Centre for Human Genome Variation Duke University Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod","family":"Radtke","sequence":"additional","affiliation":[{"name":"Centre for Human Genome Variation Duke University Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Doherty","sequence":"additional","affiliation":[{"name":"School of Medicine Trinity College Dublin Dublin Ireland"},{"name":"Department of Neurology St James's Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauls","family":"Auce","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Belfast Health and Social Care Trust Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Brain Sciences Imperial College Faculty of Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby P. C.","family":"Koeleman","sequence":"additional","affiliation":[{"name":"Center of Molecular Medicine University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9938-7126","authenticated-orcid":false,"given":"Roland","family":"Krause","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine University of Luxembourg Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram S.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony G.","family":"Marson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"The Departments of Neuroscience and Neurology The Alfred Hospital Monash University Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK"},{"name":"Chalfont Centre for Epilepsy Buckinghamshire UK"},{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme J.","family":"Sills","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hreinn","family":"Stefansson","sequence":"additional","affiliation":[{"name":"deCODE Genetics\/Amgen Inc Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-1476","authenticated-orcid":false,"given":"Pasquale","family":"Striano","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Muscular Diseases Unit DINOGMI\u2010Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Institute \"G. 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