{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T05:04:14Z","timestamp":1766466254477,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["HHSN271201600048C"],"award-info":[{"award-number":["HHSN271201600048C"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with epilepsy can experience diurnal seizure patterns. However, few studies in rodent models of temporal lobe epilepsy (TLE) routinely quantify the diurnal pattern of spontaneous recurrent seizures (SRS), and those that have conducted such assessments used small groups. This study thus aimed to define whether there was a diurnal pattern of SRS in the early phases of epileptogenesis in a large cohort (n\u00a0=\u00a040) of post\u2010kainic acid (KA)\u2010induced status epilepticus (SE) male Sprague Dawley rats. Rats were monitored by continuous 24\/7 video\u2010EEG in two\u2010week epochs up to 6\u00a0weeks post\u2010KA\u2010induced SE. The total number of SRS by 6\u00a0weeks post\u2010SE correlated to body weight at the time of SE insult (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0.1465, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0143). The total number of spontaneous behavioral and electrographic seizures, seizure severity, and seizure burden was recorded during lights ON (light) or lights OFF (dark) phases. All measures significantly increased with time post\u2010SE; we detected significantly more seizures during the lights OFF phase of the post\u2010SE monitoring periods. Moreover, a subset of rats demonstrated marked seizure preference in the lights OFF phase. Our study confirms that a diurnal pattern of SRS is variably detectable in early epileptogenesis in this model of TLE.<\/jats:p>","DOI":"10.1002\/epi4.12485","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T07:09:17Z","timestamp":1617347357000},"page":"431-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diurnal burden of spontaneous seizures in early epileptogenesis in the post\u2010kainic acid rat model of epilepsy"],"prefix":"10.1002","volume":"6","author":[{"given":"Stephanie","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Pharmacy School of Pharmacy University of Washington Seatle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachery","family":"Koneval","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmacy University of Washington Seatle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dannielle K.","family":"Zierath","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmacy University of Washington Seatle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"Knox","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmacy University of Washington Seatle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Steve","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmacy University of Washington Seatle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-0553","authenticated-orcid":false,"given":"Melissa","family":"Barker\u2010Haliski","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmacy University of Washington Seatle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000183"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31821213d4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.11.1453"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2003.10.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00632"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.08.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.02.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00911.2012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0720"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03200.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(98)00127-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107811"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0395-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701748305"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16531"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.252155"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(98)00017-5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13742"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0980-08.2009"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24414"}],"container-title":["Epilepsia Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi4.12485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi4.12485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi4.12485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:35:06Z","timestamp":1693416906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi4.12485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/epi4.12485"],"URL":"https:\/\/doi.org\/10.1002\/epi4.12485","archive":["Portico"],"relation":{},"ISSN":["2470-9239","2470-9239"],"issn-type":[{"type":"print","value":"2470-9239"},{"type":"electronic","value":"2470-9239"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"2020-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}