{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:25:07Z","timestamp":1790789107605,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent research has explored the use of continuous EEG (cEEG) monitoring for prognostication of spontaneous cardiac arrest (SCA). However, there is limited literature on the long\u2010term (post\u2010hospital discharge) electrographic findings among SCA survivors and their clinical correlates. Our study aims to fill this critical knowledge gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively used our EEG database to identify adults (\u226518\u00a0years) with SCA history who underwent an outpatient laboratory\u2010based EEG between 01\/01\/2011 and 12\/31\/2018. After electronic medical records (EMR) review, patients with epilepsy history and unclear\/poorly documented SCA history were excluded. Outpatient EEGs were reviewed by authors. Acute EEG findings were extracted from the EEG database and EMR. In addition, we extracted data on acute and long\u2010term neuroimaging findings (CT\/MRI), post\u2010SCA seizures, and anti\u2010seizure medications (ASM) status. Descriptive analysis and Fisher's exact test were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 32 SCA survivors (50% women; mean age\u00a0=\u00a052.1\u00a0\u00b1\u00a013.6\u00a0years) in the study. During a median clinical follow\u2010up of 28.2\u00a0months, 3 patients suffered only clinical seizures, 3 only chronic post\u2010hypoxic myoclonus, and 5 had both [11 (34.4%) in total]. Interictal epileptiform discharges (IEDs) were noted in one\u2010third of the patients, which localized to vertex and frontocentral regions in all but one patient. Five (15.6%) of them did not suffer a clinical seizure despite the presence of EAs. Patients who developed epilepsy were significantly more likely to have abnormal neuroimaging findings [10\/11 (90.9%)] during the follow\u2010up compared to the rest of the patients [OR\u00a0=\u00a025 (95% CI 2.6\u2013&gt;100, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002)]. Half of the study cohort was taking ASM at the last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our small study reveals a signature location of IEDs in SCA survivors. Neuroimaging abnormalities seem to be a better indicator of epilepsy development, while EEG may reveal markers of potential epileptogenicity in the absence of clinical seizures. Future, larger studies are needed to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12516","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T17:26:19Z","timestamp":1624901179000},"page":"559-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term electro\u2010clinical profile of sudden cardiac arrest survivors"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7705-394X","authenticated-orcid":false,"given":"Hussam","family":"Shaker","sequence":"first","affiliation":[{"name":"Epilepsy Center Neurological Institute Cleveland Clinic Cleveland Ohio USA"},{"name":"Epilepsy Center Mercy Health Hauenstein Center Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-352X","authenticated-orcid":false,"given":"Anna","family":"Milan","sequence":"additional","affiliation":[{"name":"Epilepsy Center Neurological Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Alsallom","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9386-7791","authenticated-orcid":false,"given":"Christopher","family":"Newey","sequence":"additional","affiliation":[{"name":"Epilepsy Center Neurological Institute Cleveland Clinic Cleveland Ohio USA"},{"name":"Cerebrovascular Center Neurological Institute Cleveland Clinic Cleveland OH USA"},{"name":"Center for Clinical Artificial Intelligence Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hantus","sequence":"additional","affiliation":[{"name":"Epilepsy Center Neurological Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-6736","authenticated-orcid":false,"given":"Vineet","family":"Punia","sequence":"additional","affiliation":[{"name":"Epilepsy Center Neurological Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.282075066"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12270"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(93)90069-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(96)70080-X"},{"key":"e_1_2_7_6_1","first-page":"21","article-title":"A glossary of terms most commonly used by clinical electroencephalographers and proposal for the report form for the EEG findings. The International Federation of Clinical Neurophysiology","volume":"52","author":"Noachtar S","year":"1999","journal-title":"Electroencephalogr Clin Neurophysiol Suppl"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.4990"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"American Clinical Neurophysiology Society Guideline 1: minimum technical requirements for performing","volume":"56","author":"Sinha SR","year":"2016","journal-title":"Clin Electroencephalogr"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.06.019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24697"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60214-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.06.030"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.323"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00039"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12393"}],"container-title":["Epilepsia Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi4.12516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi4.12516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi4.12516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:43:33Z","timestamp":1693356213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi4.12516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,13]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/epi4.12516"],"URL":"https:\/\/doi.org\/10.1002\/epi4.12516","archive":["Portico"],"relation":{},"ISSN":["2470-9239","2470-9239"],"issn-type":[{"value":"2470-9239","type":"print"},{"value":"2470-9239","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,13]]},"assertion":[{"value":"2021-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}