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Studies have shown that the prevalence of epilepsy in low\u2010 and middle\u2010income countries is substantially greater than in more resourced countries. The objective of this report was to demonstrate that mobile Health (mHealth) technologies have the potential to improve the management of epilepsy in Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The feasibility of technology\u2010based home monitoring was investigated in an observational study of 40 children with refractory epilepsy or epilepsy associated with intellectual disability and\/or behavior difficulties in South Africa. Technology\u2010based home monitoring was implemented for six months. Physical activity, sleep, and heart rate were continuously monitored with a wearable device. Caregivers completed regular mobile Patient Reported Outcomes (mPROs) and reported seizures and ad hoc events using a dedicated app. Feasibility was assessed and descriptively measured for recruitment, retention, and engagement of the participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mHealth technology was able to capture important information that gives an impression of the overall experience of the children and their caregivers. Thirty\u2010seven participants (94.9%) reported at least one clinical event. Seventy\u2010nine percent of caregivers reported seizure events in their children, which were the primary event anticipated. Median engagement with the wearable device and monthly mPROs was 30.8% and 57.1%, respectively. However, most participants (87%) had to be given smartphones for them to have Bluetooth capabilities and access to the study app. Tolerability to the device was impacted by the difficult living circumstances of caregivers that induced fear of loss or theft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The study showed how the use of remote patient monitoring in the form of mHealth can benefit epilepsy patients, despite highly variable engagement with the technology. The combination of mPROs and wearable devices generated informative datasets that will allow clinicians but also the children and their caregivers to better understand and manage the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12527","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T17:27:23Z","timestamp":1627320443000},"page":"653-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Demonstrating the feasibility of digital health to support pediatric patients in South Africa"],"prefix":"10.1002","volume":"6","author":[{"given":"Elin Haf","family":"Davies","sequence":"first","affiliation":[{"name":"Aparito Ltd Wrexham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Fieggen","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Department of Medicine University of Cape Town Observatory South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-1796","authenticated-orcid":false,"given":"Jo","family":"Wilmshurst","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Red Cross War Memorial Children\u2019s Hospital Neuroscience Institute University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obuchinezia","family":"Anyanwu","sequence":"additional","affiliation":[{"name":"Aparito Ltd Wrexham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-7871","authenticated-orcid":false,"given":"Richard Joseph","family":"Burman","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Red Cross War Memorial Children\u2019s Hospital Neuroscience Institute University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-6494","authenticated-orcid":false,"given":"Sandra","family":"Komarzynski","sequence":"additional","affiliation":[{"name":"Aparito Ltd Wrexham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003509"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022426"},{"key":"e_1_2_10_4_1","first-page":"415082","article-title":"Efficacy and Safety of Levetiracetam and Carbamazepine as Monotherapy in Partial Seizures","volume":"2015","author":"Suresh SH","year":"2015","journal-title":"Epilepsy Res Treat"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30430-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8394-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.106949"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30454-X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.10.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/20786190.2015.1078152"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3402\/qhw.v11.30213"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4102\/curationis.v42i1.1901"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.06.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12914-016-0084-0"},{"key":"e_1_2_10_15_1","series-title":"Global Observatory for eHealth series","volume-title":"MHealth: new horizons for health through mobile technologies","author":"WHO Global Observatory for eHealth","year":"2011"},{"key":"e_1_2_10_16_1","unstructured":"GillwaldA MoyoM&StorkC. 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