{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:24:24Z","timestamp":1787505864034,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DC013315\u201007"],"award-info":[{"award-number":["R01 DC013315\u201007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 DC019217\u201001A1"],"award-info":[{"award-number":["R21 DC019217\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Febrile infection\u2010related epilepsy syndrome (FIRES) is a rare, life\u2010threatening complication of febrile illness in previously healthy individuals followed by super\u2010refractory status epilepticus. Deep brain stimulation (DBS) has been demonstrated to be a promising therapy for the treatment of intractable epilepsy. Here, we present a pediatric patient with FIRES whose seizures were mitigated by acute DBS of the bilateral centromedian thalamic nucleus (CMTN). This is a previously healthy 11\u2010year\u2010old female who presented emergently with altered mental status, fever, and malaise after 1\u00a0week of lethargy, anorexia, fever, and abdominal pain. The patient began having seizures shortly after admission. After thorough workup for encephalitis and other potential etiologies, this patient was diagnosed with FIRES due to super\u2010refractory status epilepticus. Status epilepticus persisted despite pharmacologic management, immunotherapy, and vagus nerve stimulation. DBS of the bilateral CMTN (CM\u2010DBS) was pursued after 56\u00a0days of hospitalization, and she demonstrated considerable improvement in baseline mental status 30\u00a0days after DBS insertion. This report highlights application of CM\u2010DBS for super\u2010refractory status epilepticus in FIRES. This region is a diffusely connected brain region and has been shown to modulate neural networks contributing to seizure propagation and consciousness; therefore, neurostimulation is a potential therapeutic intervention for patients with super\u2010refractory status epilepticus.<\/jats:p>","DOI":"10.1002\/epi4.12568","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T06:45:18Z","timestamp":1638600318000},"page":"187-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Deep brain stimulation of the centromedian thalamic nucleus for the treatment of FIRES"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-2394","authenticated-orcid":false,"given":"Jasmine L.","family":"Hect","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis D.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Welch","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5089-460X","authenticated-orcid":false,"given":"Taylor J.","family":"Abel","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"},{"name":"Department of Bioengineering University of Pittsburgh Swanson School of Engineering Pittsburgh Pennsylvania 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