{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:15:05Z","timestamp":1790806505592,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interictal 18F\u2010Fluorodeoxyglucose positron emission tomography (FDG\u2010PET) is used in the workup for epilepsy surgery when MRI and EEG video monitoring are not conclusive. Timing of FDG\u2010PET is crucial to avoid the metabolically dynamic (post)ictal state that complicates interpretation, but the exact time window is unclear. We performed a systematic review to provide an evidence\u2010based recommendation for the minimal time interval between last seizure and FDG\u2010PET acquisition. We searched PubMed and Embase for articles on the effect of time since last seizure on FDG\u2010PET outcome. Quality assessment was conducted with the Critical Appraisal Skills Programme Cohort Study Checklist. We identified five studies. Three studies were classified as of low to moderate quality, mainly due to undocumented data or insufficient statistical measurements. Two high\u2010quality studies included only adults with Temporal Lobe Epilepsy (TLE). The metabolic interictal phase is 24 or 48\u00a0hours after the last seizure, depending on seizure type. The recommendation is based on the best available evidence from two small study populations for TLE. If clinically possible, interictal FDG\u2010PET in adults should be performed at least 24\u00a0hours after focal aware seizures and 48\u00a0hours after focal impaired awareness and focal to bilateral tonic\u2013clonic seizures.<\/jats:p>","DOI":"10.1002\/epi4.12617","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T14:58:25Z","timestamp":1654354705000},"page":"512-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Optimal timing of interictal <scp>FDG\u2010PET<\/scp> for epilepsy surgery: A systematic review on time since last seizure"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4010-6323","authenticated-orcid":false,"given":"Nienke N.","family":"de Laat","sequence":"first","affiliation":[{"name":"Utrecht University  Utrecht The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Department of Neurology and Neurosurgery University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelleke","family":"Tolboom","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-3364","authenticated-orcid":false,"given":"Frans S. 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