{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:14:09Z","timestamp":1790255649336,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012628","name":"Japan Epilepsy Research Foundation","doi-asserted-by":"publisher","award":["22007"],"award-info":[{"award-number":["22007"]}],"id":[{"id":"10.13039\/501100012628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K15720"],"award-info":[{"award-number":["JP21K15720"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Psychosis is an important comorbidity in epilepsy, but its pathophysiology is still unknown. The imaging modality <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose\u2010positron emission tomography (<jats:sup>18<\/jats:sup>F\u2010FDG PET) is widely used to measure brain glucose metabolism, and we speculated that <jats:sup>18<\/jats:sup>F\u2010FDG PET may detect characteristic alteration patterns in individuals with temporal lobe epilepsy (TLE) and psychosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 13 patients with TLE and interictal psychosis (TLE\u2010P) and 21 patients with TLE without psychosis (TLE\u2010N). All underwent interictal <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET scanning. Statistical Parametric Mapping (SPM)12 software was used for the normalization process, and we performed a voxel\u2010wise comparison of the TLE\u2010P and TLE\u2010N groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cerebral hypometabolic areas were observed in the ipsilateral temporal pole to hippocampus in both patient groups. In the TLE\u2010P group, the voxel\u2010wise comparison revealed significantly increased <jats:sup>18<\/jats:sup>F\u2010FDG signals in the upper cerebellum, superior cerebellar peduncle, and midbrain. There were no significant between\u2010group metabolic differences around the focus or other cerebral areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our results demonstrated significant hypermetabolism around the upper cerebellum in patients with TLE and interictal psychosis compared to patients with TLE without psychosis. These findings may reflect the involvement of the cerebellum in the underlying neurobiology of interictal psychosis and could contribute to a better understanding of this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12645","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T01:29:27Z","timestamp":1660786167000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Upper cerebellar glucose hypermetabolism in patients with temporal lobe epilepsy and interictal psychosis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9617-706X","authenticated-orcid":false,"given":"Daichi","family":"Sone","sequence":"first","affiliation":[{"name":"Department of Radiology National Center of Neurology and Psychiatry  Tokyo Japan"},{"name":"Department of Psychiatry Jikei University School of Medicine  Tokyo 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