{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:45:09Z","timestamp":1792896309193,"version":"4.5.0"},"reference-count":439,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Status epilepticus (SE) remains a significant cause of morbidity and mortality and often is refractory to standard first\u2010line treatments. A rapid loss of synaptic inhibition and development of pharmacoresistance to benzodiazepines (BZDs) occurs early during SE, while NMDA and AMPA receptor antagonists remain effective treatments after BZDs have failed. Multimodal and subunit\u2010selective receptor trafficking within minutes to an hour of SE involves GABA\u2010A, NMDA, and AMPA receptors and contributes to shifts in the number and subunit composition of surface receptors with differential impacts on the physiology, pharmacology, and strength of GABAergic and glutamatergic currents at synaptic and extrasynaptic sites. During the first hour of SE, synaptic GABA\u2010A receptors containing \u03b32 subunits move to the cell interior while extrasynaptic GABA\u2010A receptors with \u03b4 subunits are preserved. Conversely, NMDA receptors containing N2B subunits are increased at synaptic and extrasynaptic sites, and homomeric GluA1 (\u201cGluA2\u2010lacking\u201d) calcium permeant AMPA receptor surface expression also is increased. Molecular mechanisms, largely driven by NMDA receptor or calcium permeant AMPA receptor activation early during circuit hyperactivity, regulate subunit\u2010specific interactions with proteins involved with synaptic scaffolding, adaptin\u2010AP2\/clathrin\u2010dependent endocytosis, endoplasmic reticulum (ER) retention, and endosomal recycling. Reviewed here is how SE\u2010induced shifts in receptor subunit composition and surface representation increase the excitatory to inhibitory imbalance that sustains seizures and fuels excitotoxicity contributing to chronic sequela such as \u201cspontaneous recurrent seizures\u201d (SRS). A role for early multimodal therapy is suggested both for treatment of SE and for prevention of long\u2010term comorbidities.<\/jats:p>","DOI":"10.1002\/epi4.12718","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T09:59:51Z","timestamp":1677751191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["In the fast lane: Receptor trafficking during status epilepticus"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-1795","authenticated-orcid":false,"given":"David E.","family":"Naylor","sequence":"first","affiliation":[{"name":"VA Greater Los Angeles Healthcare System, Department of Neurology David Geffen School of Medicine at UCLA, and The Lundquist Institute at Harbor\u2010UCLA Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.1029"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.1.139"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199804000-00012"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809173391202"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(88)90010-6"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa002141"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01080-4"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107494"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00606-4"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90268-8"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000196333.16608.30"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.2.205"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06425-3"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000310774.01185.97"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.11.855"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0387-7604(02)00230-9"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70178-2"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(02)00085-2"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07532.1997"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1995.tb00979.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.10.004"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.43.s.5.25.x"},{"issue":"5","key":"e_1_2_13_24_1","first-page":"13","article-title":"The biochemical basis and pathophysiology of status epilepticus","volume":"40","author":"Lothman E","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01285-7"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00658.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00215-4"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.015"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.012"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/7263"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2555-04.2004"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.12.006"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014478"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2356"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90046-2"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/375400a0"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.046"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.035"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.002"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00979-0"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00780"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.05.029"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1270"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1890-04.2004"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2003.03074.x"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1303"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608492103"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3159-04.2004"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.08.008"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-20-08902.2002"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.05.018"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00122-3"},{"key":"e_1_2_13_53_1","volume-title":"Biology of the NMDA Receptor","author":"Salter MW","year":"2009"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5421.1811"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-05-01693.1998"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4346-07.2008"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00826.2003"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00356-8"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.04.023"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506653102"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000589107"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04837.x"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00633-5"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1503"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/35056583"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.015"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108444"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01305.x"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.11.013"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.61.2.427"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00238-4"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)80023-3"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/2798"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00442-5"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47131-1"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2370"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/338582a0"},{"issue":"3","key":"e_1_2_13_78_1","first-page":"567","article-title":"Properties of putative cerebellar gamma\u2010aminobutyric acid a receptor isoforms","volume":"49","author":"Saxena NC","year":"1996","journal-title":"Mol Pharmacol"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.316836"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90224-4"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.020255"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.027af.x"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00640.x"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-22-09922.2002"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-11-04654.1999"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704795"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj055"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.182444"},{"issue":"5","key":"e_1_2_13_89_1","first-page":"1253","article-title":"Pharmacological modulation of the diazepam\u2010insensitive recombinant gamma\u2010aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2","volume":"50","author":"Knoflach F","year":"1996","journal-title":"Mol Pharmacol"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4751-07.2008"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/366565a0"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00649.x"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6121-11.2012"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1734-08.2008"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0204-05.2005"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-20-07626.1997"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00555-1"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0746"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.10.010"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00064-3"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90316-6"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12957-8"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-13-05062.1997"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-21-07972.2000"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380609"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4944-04.2005"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80382-7"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2015.11.006"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0900-05.2005"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.08.003"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25213"},{"key":"e_1_2_13_112_1","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1684\/epd.2014.0691","article-title":"Treating acute seizures with benzodiazepines: does seizure duration matter?","volume":"16","author":"Naylor DE","year":"2014","journal-title":"Epileptic Disord"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3426-07.2008"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021806"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(90)90008-G"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00967257"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.134460"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0471-2"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42291-5"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb08295.x"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02622.x"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.43.s.5.37.x"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(90)90025-Q"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13098"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12552"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00693-9"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(90)90036-U"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90569-U"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2004.03.004"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1059-1311(03)00028-1"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00132-3"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb01572.x"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.256.5060.1217"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.43.100901.135803"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0310885"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-16-06844.1999"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2552004re16"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1613-05.2005"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-07-02469.1997"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1221-05.2005"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-34-10791.2003"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0829-13.2013"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.035"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-04958.2003"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605238103"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00169.x"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.080"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.02.011"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00771.2005"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-04180.1999"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1905-05.2005"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn912"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1697-04.2004"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.013bu.x"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2911"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858407305833"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.123570"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.029"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3836-12.2013"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00776-6"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1279803"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90210-0"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-03-01260.2000"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1556"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.12.003"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20383"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01664.x"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12876"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-9639(02)00455-7"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)00040-1"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.03.030"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.02.045"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.011"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/90498"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2153"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb990"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00161-6"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.09.008"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108104"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80962-9"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2488"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00658-X"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.06.008"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.04.031"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0780-04.2004"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569905"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07351.1997"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.3269"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2804"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.06.003"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.034"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1517"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(03)00308-3"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.060805.160029"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.01.006"},{"issue":"2","key":"e_1_2_13_196_1","first-page":"342","article-title":"Alterations in subunit expression, composition, and phosphorylation of striatal N\u2010methyl\u2010D\u2010aspartate glutamate receptors in a rat 6\u2010hydroxydopamine model of Parkinson's disease","volume":"57","author":"Dunah AW","year":"2000","journal-title":"Mol Pharmacol"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.11.006"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.016"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0546-04.2004"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1013"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.002451"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01044-10"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3290"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2427"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3117"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.05.033"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.05.003"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04439-7"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.10.003"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-420170-5.00003-9"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.10232"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.09.024"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05140.x"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858411435129"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008085200"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065983"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/369233a0"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1716001"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-14-05079.2001"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-09-03063.2001"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1664"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.8.5157"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81150-2"},{"issue":"4","key":"e_1_2_13_224_1","first-page":"337","article-title":"STEP: a family of brain\u2010enriched PTPs. Alternative splicing produces transmembrane, cytosolic and truncated isoforms","volume":"72","author":"Bult A","year":"1997","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900878116"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609702113"},{"key":"e_1_2_13_227_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0157-10.2010"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0148-4"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013543107"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111683200"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.1038\/5680"},{"key":"e_1_2_13_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.030"},{"key":"e_1_2_13_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2009.02.004"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609924104"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00216-6"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3319-x"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.2741\/s38"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds154"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0203-11.2011"},{"key":"e_1_2_13_240_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306832110"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2433"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110002"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02057.x"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400512"},{"key":"e_1_2_13_245_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1989.70.4.0578"},{"key":"e_1_2_13_246_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.13.030190.001131"},{"key":"e_1_2_13_247_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04600.2001"},{"key":"e_1_2_13_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2009.01.002"},{"key":"e_1_2_13_249_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.6.0889"},{"key":"e_1_2_13_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.12.015"},{"key":"e_1_2_13_251_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(20000601)60:5<632::AID-JNR8>3.0.CO;2-3"},{"key":"e_1_2_13_252_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1277"},{"key":"e_1_2_13_253_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07628.x"},{"key":"e_1_2_13_254_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.795"},{"key":"e_1_2_13_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.011"},{"key":"e_1_2_13_256_1","doi-asserted-by":"publisher","DOI":"10.1038\/35058528"},{"key":"e_1_2_13_257_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1849"},{"key":"e_1_2_13_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00237-6"},{"key":"e_1_2_13_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01445-9"},{"key":"e_1_2_13_260_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2001-07.2007"},{"key":"e_1_2_13_261_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063214"},{"key":"e_1_2_13_262_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.02977.x"},{"key":"e_1_2_13_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00231-5"},{"key":"e_1_2_13_264_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.04.024"},{"key":"e_1_2_13_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.04.040"},{"key":"e_1_2_13_266_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.19205.x"},{"key":"e_1_2_13_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.02.054"},{"key":"e_1_2_13_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02100-9"},{"key":"e_1_2_13_269_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00971859"},{"key":"e_1_2_13_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90490-3"},{"key":"e_1_2_13_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90903-M"},{"key":"e_1_2_13_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02623-8"},{"key":"e_1_2_13_273_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00462-5"},{"key":"e_1_2_13_274_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.4.1253"},{"key":"e_1_2_13_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.05.066"},{"issue":"2","key":"e_1_2_13_276_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.55782\/ane-2011-1842","article-title":"Pilocarpine\u2010induced status epilepticus alters hippocampal PKC expression in mice","volume":"71","author":"Liu JX","year":"2011","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"e_1_2_13_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.08.018"},{"key":"e_1_2_13_278_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00426.x"},{"key":"e_1_2_13_279_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4913-06.2007"},{"key":"e_1_2_13_280_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17192"},{"key":"e_1_2_13_281_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02912.x"},{"key":"e_1_2_13_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.02.027"},{"key":"e_1_2_13_283_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-06-01982.1996"},{"key":"e_1_2_13_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90076-4"},{"key":"e_1_2_13_285_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-08-03005.2002"},{"key":"e_1_2_13_286_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3952506"},{"key":"e_1_2_13_287_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20972"},{"key":"e_1_2_13_288_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02112.2003"},{"key":"e_1_2_13_289_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08422.2002"},{"key":"e_1_2_13_290_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3214"},{"key":"e_1_2_13_291_1","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_2_13_292_1","doi-asserted-by":"publisher","DOI":"10.1038\/320529a0"},{"key":"e_1_2_13_293_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90193-6"},{"key":"e_1_2_13_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.03.040"},{"key":"e_1_2_13_295_1","doi-asserted-by":"publisher","DOI":"10.1038\/305719a0"},{"key":"e_1_2_13_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.09.002"},{"key":"e_1_2_13_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.014"},{"key":"e_1_2_13_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.02.010"},{"key":"e_1_2_13_299_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3504"},{"key":"e_1_2_13_300_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0477-04.2004"},{"key":"e_1_2_13_301_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2016.08.002"},{"key":"e_1_2_13_302_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81119-8"},{"key":"e_1_2_13_303_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142758"},{"key":"e_1_2_13_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2010.08.014"},{"key":"e_1_2_13_305_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111146298"},{"key":"e_1_2_13_306_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4363"},{"key":"e_1_2_13_307_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.025"},{"key":"e_1_2_13_308_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2699"},{"key":"e_1_2_13_309_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3192"},{"key":"e_1_2_13_310_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90248-C"},{"key":"e_1_2_13_311_1","doi-asserted-by":"publisher","DOI":"10.1038\/369486a0"},{"key":"e_1_2_13_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.04.035"},{"key":"e_1_2_13_313_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.009"},{"key":"e_1_2_13_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.01.004"},{"key":"e_1_2_13_315_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011706107"},{"key":"e_1_2_13_316_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1184178"},{"key":"e_1_2_13_317_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.37"},{"key":"e_1_2_13_318_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00640-8"},{"key":"e_1_2_13_319_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2262"},{"key":"e_1_2_13_320_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5068-11.2012"},{"key":"e_1_2_13_321_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2474"},{"key":"e_1_2_13_322_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1678"},{"key":"e_1_2_13_323_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00321-X"},{"key":"e_1_2_13_324_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211132798"},{"key":"e_1_2_13_325_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-27-09220.2003"},{"key":"e_1_2_13_326_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.52.32727"},{"key":"e_1_2_13_327_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80144-0"},{"key":"e_1_2_13_328_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2042"},{"key":"e_1_2_13_329_1","doi-asserted-by":"publisher","DOI":"10.1038\/35016089"},{"key":"e_1_2_13_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(03)00267-3"},{"key":"e_1_2_13_331_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80633-9"},{"key":"e_1_2_13_332_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80632-7"},{"key":"e_1_2_13_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.023"},{"key":"e_1_2_13_334_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007644128886"},{"key":"e_1_2_13_335_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2852"},{"key":"e_1_2_13_336_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.18648"},{"key":"e_1_2_13_337_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082915"},{"key":"e_1_2_13_338_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-19-07258.2000"},{"key":"e_1_2_13_339_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.731765.x"},{"key":"e_1_2_13_340_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.06.015"},{"key":"e_1_2_13_341_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5435.1870"},{"key":"e_1_2_13_342_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.028"},{"key":"e_1_2_13_343_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(03)00336-8"},{"key":"e_1_2_13_344_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600801"},{"key":"e_1_2_13_345_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.11.011"},{"key":"e_1_2_13_346_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11775"},{"key":"e_1_2_13_347_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913875107"},{"key":"e_1_2_13_348_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.03.017"},{"key":"e_1_2_13_349_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23570"},{"key":"e_1_2_13_350_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12266"},{"key":"e_1_2_13_351_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25635"},{"key":"e_1_2_13_352_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.10.010"},{"key":"e_1_2_13_353_1","article-title":"Synaptic non\u2010NMDA currents increase in dentate gyrus granule cells during status epilepticus","volume":"35","author":"Naylor DE","year":"2005","journal-title":"Soc Neurosci"},{"key":"e_1_2_13_354_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.04.024"},{"key":"e_1_2_13_355_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00230-5"},{"key":"e_1_2_13_356_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00128-8"},{"key":"e_1_2_13_357_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3326-12.2012"},{"key":"e_1_2_13_358_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.01.015"},{"key":"e_1_2_13_359_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(00)00175-3"},{"key":"e_1_2_13_360_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12289"},{"key":"e_1_2_13_361_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13999"},{"key":"e_1_2_13_362_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00985-5"},{"key":"e_1_2_13_363_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.09.014"},{"key":"e_1_2_13_364_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.112.084715"},{"key":"e_1_2_13_365_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.06.011"},{"key":"e_1_2_13_366_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5421.1805"},{"key":"e_1_2_13_367_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107229"},{"key":"e_1_2_13_368_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01384.x"},{"key":"e_1_2_13_369_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14479"},{"key":"e_1_2_13_370_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13695"},{"key":"e_1_2_13_371_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.04.019"},{"issue":"3","key":"e_1_2_13_372_1","first-page":"670","article-title":"Functional characterization of human gamma\u2010aminobutyric acidA receptors containing the alpha 4 subunit","volume":"50","author":"Wafford KA","year":"1996","journal-title":"Mol Pharmacol"},{"key":"e_1_2_13_373_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2877-04.2004"},{"key":"e_1_2_13_374_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1555-07.2007"},{"key":"e_1_2_13_375_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.07.016"},{"key":"e_1_2_13_376_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710522105"},{"key":"e_1_2_13_377_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00301.x"},{"key":"e_1_2_13_378_1","doi-asserted-by":"publisher","DOI":"10.1038\/2661"},{"issue":"3","key":"e_1_2_13_379_1","first-page":"444","article-title":"Postnatal development of hippocampal dentate granule cell gamma\u2010aminobutyric acidA receptor pharmacological properties","volume":"55","author":"Kapur J","year":"1999","journal-title":"Mol Pharmacol"},{"key":"e_1_2_13_380_1","doi-asserted-by":"publisher","DOI":"10.1038\/16697"},{"key":"e_1_2_13_381_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09235.2000"},{"key":"e_1_2_13_382_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01894.x"},{"key":"e_1_2_13_383_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.067983"},{"key":"e_1_2_13_384_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb02130.x"},{"key":"e_1_2_13_385_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2786-07.2007"},{"key":"e_1_2_13_386_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(95)00044-G"},{"key":"e_1_2_13_387_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24295"},{"key":"e_1_2_13_388_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.408"},{"key":"e_1_2_13_389_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1747-14.2014"},{"key":"e_1_2_13_390_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-20-07662.1997"},{"key":"e_1_2_13_391_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7638623"},{"key":"e_1_2_13_392_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318278b685"},{"key":"e_1_2_13_393_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2013.01.007"},{"key":"e_1_2_13_394_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12247"},{"key":"e_1_2_13_395_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.07.004"},{"key":"e_1_2_13_396_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-019-00738-z"},{"key":"e_1_2_13_397_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13061"},{"key":"e_1_2_13_398_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-021-03053-9"},{"key":"e_1_2_13_399_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12627"},{"key":"e_1_2_13_400_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2017.11.009"},{"key":"e_1_2_13_401_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.04.006"},{"key":"e_1_2_13_402_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1973.tb08267.x"},{"key":"e_1_2_13_403_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00027-7"},{"key":"e_1_2_13_404_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1990.tb05492.x"},{"key":"e_1_2_13_405_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1453"},{"key":"e_1_2_13_406_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90002-L"},{"key":"e_1_2_13_407_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10085"},{"key":"e_1_2_13_408_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22035"},{"key":"e_1_2_13_409_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90121-X"},{"key":"e_1_2_13_410_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.01.025"},{"key":"e_1_2_13_411_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2005.03.007"},{"key":"e_1_2_13_412_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(90)90095-D"},{"key":"e_1_2_13_413_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.07.005"},{"key":"e_1_2_13_414_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-06-02153.2002"},{"key":"e_1_2_13_415_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.008"},{"key":"e_1_2_13_416_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(99)00108-4"},{"key":"e_1_2_13_417_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00130.x"},{"key":"e_1_2_13_418_1","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2002.0677"},{"key":"e_1_2_13_419_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4129-11.2012"},{"key":"e_1_2_13_420_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02229072"},{"key":"e_1_2_13_421_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90681-6"},{"key":"e_1_2_13_422_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.019"},{"key":"e_1_2_13_423_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.03.009"},{"issue":"5","key":"e_1_2_13_424_1","first-page":"545","article-title":"The seizures induced by pilocarpine: behavioral, electroencephalographic and neuropathological studies in rodents","volume":"39","author":"Turski L","year":"1987","journal-title":"Pol J Pharmacol Pharm"},{"key":"e_1_2_13_425_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890030207"},{"key":"e_1_2_13_426_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(83)90136-5"},{"key":"e_1_2_13_427_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13660"},{"key":"e_1_2_13_428_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12378"},{"key":"e_1_2_13_429_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-21-09519.1999"},{"key":"e_1_2_13_430_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10183"},{"issue":"5","key":"e_1_2_13_431_1","first-page":"513","article-title":"The role of cortical and hippocampal Gabaergic interneurons in epilepsy","volume":"102","author":"Zaitsev AV","year":"2016","journal-title":"Rossiiskii Fiziologicheskii Zhurnal Imeni IM Sechenova"},{"key":"e_1_2_13_432_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90234-5"},{"key":"e_1_2_13_433_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03990.1995"},{"key":"e_1_2_13_434_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290316"},{"key":"e_1_2_13_435_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2879352"},{"key":"e_1_2_13_436_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00523.2018"},{"key":"e_1_2_13_437_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1060"},{"key":"e_1_2_13_438_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4049-15.2016"},{"key":"e_1_2_13_439_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22235"},{"key":"e_1_2_13_440_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14723"}],"container-title":["Epilepsia Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi4.12718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi4.12718","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi4.12718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T03:42:22Z","timestamp":1702006942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi4.12718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":439,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/epi4.12718"],"URL":"https:\/\/doi.org\/10.1002\/epi4.12718","archive":["Portico"],"relation":{},"ISSN":["2470-9239","2470-9239"],"issn-type":[{"value":"2470-9239","type":"print"},{"value":"2470-9239","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,20]]},"assertion":[{"value":"2022-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}