{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:42:28Z","timestamp":1790131348932,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["12345"],"award-info":[{"award-number":["12345"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to explore the underlying pathomechanisms of the comorbidity between three common systemic autoimmune disorders (SADs) [i.e., insulin\u2010dependent diabetes mellitus (IDDM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA)] and temporal lobe epilepsy (TLE), using bioinformatics tools. We hypothesized that there are shared genetic variations among these four conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Different databases (DisGeNET, Harmonizome, and Enrichr) were searched to find TLE\u2010associated genes with variants; their single nucleotide polymorphisms (SNPs) were gathered from the literature. We also did a separate literature search using PubMed with the following keywords for original articles: \u201cTLE\u201d or \u201cTemporal lobe epilepsy\u201d AND \u201cgenetic variation,\u201d \u201csingle nucleotide polymorphism,\u201d \u201cSNP,\u201d or \u201cgenetic polymorphism.\u201d In the next step, the SNPs associated with TLE were searched in the LitVar database to find the shared gene variations with RA, SLE, and IDDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety unique SNPs were identified to be associated with TLE. LitVar search identified two SNPs that were shared between TLE and all three SADs (i.e., IDDM, SLE, and RA). The first SNP was <jats:italic>rs16944<\/jats:italic> on the Interleukin\u20101\u03b2 (IL\u20101\u03b2) gene. The second genetic variation was <jats:italic>\u03b54<\/jats:italic> variation of apolipoprotein E (APOE) gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The shared genetic variations (i.e., <jats:italic>rs16944<\/jats:italic> on the IL\u20101\u03b2 gene and <jats:italic>\u03b54<\/jats:italic> variation of the APOE gene) may explain the underlying pathomechanisms of the comorbidity between three common SADs (i.e., IDDM, SLE, and RA) and TLE. Exploring such shared genetic variations may help find targeted therapies for patients with TLE, especially those with drug\u2010resistant seizures who also have comorbid SADs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12727","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T13:05:10Z","timestamp":1679058310000},"page":"509-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study"],"prefix":"10.1002","volume":"8","author":[{"given":"Mahdi","family":"Malekpour","sequence":"first","affiliation":[{"name":"Epilepsy Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Reza","family":"Salarikia","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center Shiraz University of Medical 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