{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:52:57Z","timestamp":1773640377554,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017021","name":"Mirowski Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["EB009384"],"award-info":[{"award-number":["EB009384"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS073801"],"award-info":[{"award-number":["NS073801"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS075270"],"award-info":[{"award-number":["NS075270"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS091006"],"award-info":[{"award-number":["NS091006"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS097618"],"award-info":[{"award-number":["NS097618"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS099348"],"award-info":[{"award-number":["NS099348"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS108445"],"award-info":[{"award-number":["NS108445"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS110130"],"award-info":[{"award-number":["NS110130"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS112252"],"award-info":[{"award-number":["NS112252"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epilepsy surgery is an effective treatment for drug\u2010resistant patients. However, how different surgical approaches affect long\u2010term brain structure remains poorly characterized. Here, we present a semiautomated method for quantifying structural changes after epilepsy surgery and compare the remote structural effects of two approaches, anterior temporal lobectomy (ATL), and selective amygdalohippocampectomy (SAH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 36 temporal lobe epilepsy patients who underwent resective surgery (ATL\u2009=\u200922, SAH\u2009=\u200914). All patients received same\u2010scanner MR imaging preoperatively and postoperatively (mean 2\u2009years). To analyze postoperative structural changes, we segmented the resection zone and modified the Advanced Normalization Tools (ANTs) longitudinal cortical pipeline to account for resections. We compared global and regional annualized cortical thinning between surgical treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across procedures, there was significant cortical thinning in the ipsilateral insula, fusiform, pericalcarine, and several temporal lobe regions outside the resection zone as well as the contralateral hippocampus. Additionally, increased postoperative cortical thickness was seen in the supramarginal gyrus. Patients treated with ATL exhibited greater annualized cortical thinning compared with SAH cases (ATL: \u22120.08\u2009\u00b1\u20090.11\u2009mm per year, SAH: \u22120.01\u2009\u00b1\u20090.02\u2009mm per year,\n                      <jats:italic>t<\/jats:italic>\n                      \u2009=\u20092.99,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006). There were focal postoperative differences between the two treatment groups in the ipsilateral insula (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.039, corrected). Annualized cortical thinning rates correlated with preoperative cortical thickness (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.60,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and had weaker associations with age at surgery (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.33,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.051) and disease duration (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.42,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.058).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our evidence suggests that selective procedures are associated with less cortical thinning and that earlier surgical intervention may reduce long\u2010term impacts on brain structure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi4.12733","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T23:29:34Z","timestamp":1679441374000},"page":"559-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Remote effects of temporal lobe epilepsy surgery: Long\u2010term morphological changes after surgical resection"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-8497","authenticated-orcid":false,"given":"T. Campbell","family":"Arnold","sequence":"first","affiliation":[{"name":"Department of Bioengineering, School of Engineering &amp; Applied Science University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Center for Neuroengineering and Therapeutics University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lohith G.","family":"Kini","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Engineering &amp; Applied Science University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Center for Neuroengineering and Therapeutics University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Bernabei","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Engineering &amp; Applied Science University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Center for Neuroengineering and Therapeutics University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Y.","family":"Revell","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Department of Neuroscience, School of Engineering &amp; Applied Science University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhitsu R.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Radiology, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy H.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Department of Neurosurgery, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8373-690X","authenticated-orcid":false,"given":"Dario J.","family":"Englot","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Institute of Imaging Science Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-2324","authenticated-orcid":false,"given":"Victoria L.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Institute of Imaging Science Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Litt","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Engineering &amp; 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