{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:37:13Z","timestamp":1792035433739,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study evaluated sleep and respiratory abnormalities, and their relationship with seizures, in adults with developmental and epileptic encephalopathies (DEEs). We studied consecutive adults with DEEs undergoing inpatient video\u2010EEG monitoring and concurrent polysomnography between December 2011 and July 2022. Thirteen patients with DEEs were included (median age: 31\u2009years, range: 20\u201350; 69.2% female): Lennox\u2013Gastaut syndrome (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096), Lennox\u2013Gastaut syndrome\u2010like phenotype (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), Landau\u2013Kleffner syndrome (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091), epilepsy with myoclonic\u2010atonic seizures (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091), and unclassified DEEs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093). Sleep architecture was often fragmented by epileptiform discharges and seizures resulting in arousals (median arousal index: 29.0 per h, range: 5.1\u201365.3). Moderate\u2010to\u2010severe obstructive sleep apnea (OSA) was observed in seven patients (53.8%). Three patients (23.1%) had tonic seizures that frequently occurred with central apnea; one met criteria for mild central sleep apnea. Of the patients with tonic seizures, two had other identifiable seizure manifestations, but in one patient, central apnea was commonly the only discernable seizure manifestation. Polysomnography during video\u2010EEG is an effective diagnostic tool in detecting sleep and seizure\u2010related respiratory abnormalities. Clinically significant OSA may increase the risk of comorbid cardiovascular disease and premature mortality. Treatment of epilepsy may improve sleep quality, and conversely, improved sleep, may decrease seizure burden.\n                  <\/jats:p>","DOI":"10.1002\/epi4.12772","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T04:29:06Z","timestamp":1686112146000},"page":"1157-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sleep and respiratory abnormalities in adults with developmental and epileptic encephalopathies using polysomnography and\n                    <scp>video\u2010EEG<\/scp>\n                    monitoring"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-9579","authenticated-orcid":false,"given":"Shobi","family":"Sivathamboo","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-4593","authenticated-orcid":false,"given":"Kenneth A.","family":"Myers","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre  Montreal Quebec Canada"},{"name":"Department of Pediatrics, Montreal Children's Hospital McGill University  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Montreal Children's Hospital McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pattichis","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Respiratory Medicine Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise J.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Neurology The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Nyuk","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-8621","authenticated-orcid":false,"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7855-7066","authenticated-orcid":false,"given":"Piero","family":"Perucca","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"},{"name":"Bladin\u2010Berkovic Comprehensive Epilepsy Program Austin Health  Heidelberg Victoria Australia"},{"name":"Epilepsy Research Centre, Department of Medicine (Austin Health) The University of Melbourne  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-276X","authenticated-orcid":false,"given":"Patrick","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz173"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94999"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13601"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.12.021"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.908911"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.01.017"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17241"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006776"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2013.02.015"},{"key":"e_1_2_12_12_1","volume-title":"International Classification of Sleep Disorders","author":"AASM","year":"2014"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.08.032"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.5935\/1984-0063.20220045"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17329"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-4-9"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy015"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26053"}],"container-title":["Epilepsia Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi4.12772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:46:52Z","timestamp":1693547212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi4.12772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/epi4.12772"],"URL":"https:\/\/doi.org\/10.1002\/epi4.12772","archive":["Portico"],"relation":{},"ISSN":["2470-9239","2470-9239"],"issn-type":[{"value":"2470-9239","type":"print"},{"value":"2470-9239","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]},"assertion":[{"value":"2023-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}