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We utilized two\u2010tensor tractography and fiber clustering to compare fractional anisotropy (FA) of each side\/tract between groups. Additionally, we examined the association between FA and nonverbal (WMS\u2010R) and verbal (WMS\u2010R, RAVLT codification) memory performance for MTLE individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>White matter abnormalities depended on the side and presence of HS. The left\u2010HS demonstrated widespread abnormalities for all tracts, the right\u2010HS showed lower FA for ipsilateral tracts and the nonlesional MTLE group did not differ from healthy individuals. Results indicate no differences in verbal\/nonverbal memory performance between the groups, but trend\u2010level associations between higher FA of visual memory and the left CB (<jats:italic>r<\/jats:italic>\u2009=\u20090.286, <jats:italic>P<\/jats:italic>\u2009=\u20090.018), verbal memory (RAVLT) and \u2010left CB (<jats:italic>r<\/jats:italic>\u2009=\u20090.335, <jats:italic>P<\/jats:italic>\u2009=\u20090.005), \u2010right CB (<jats:italic>r<\/jats:italic>\u2009=\u20090.286, <jats:italic>P<\/jats:italic>\u2009=\u20090.016), and \u2010left AF (<jats:italic>r<\/jats:italic>\u2009=\u20090.287, <jats:italic>P<\/jats:italic>\u2009=\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our results highlight that the presence and side of HS are crucial to understand the pathophysiology of MTLE. Specifically, left\u2010sided HS seems to be related to widespread bilateral white matter abnormalities. Future longitudinal studies should focus on developing diagnostic and treatment strategies dependent on HS's presence\/side.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12793","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T05:53:46Z","timestamp":1689832426000},"page":"1111-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-4332","authenticated-orcid":false,"given":"Tamires A.","family":"Zanao","sequence":"first","affiliation":[{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Neuroimaging Laboratory, School of Medical Sciences University of Campinas 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