{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:08:45Z","timestamp":1790197725943,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is growing evidence that ketogenic dietary therapy (KDT) can be safely and efficiently used in young children, but little evidence exists on its use in newborns. Developmental and epileptic encephalopathies starting in the neonatal period or early infancy usually present a poor prognosis. The aim of this study was to evaluate effectiveness, safety, and survival of infants younger than 3\u2009months of age with drug\u2010resistant epilepsy in whom KDT was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted to evaluate neonates and infants younger than 3\u2009months who started KDT for drug\u2010resistant developmental and epileptic encephalopathies at three referral centers. Data were collected on demographic features, time of epilepsy onset, epilepsy syndrome, seizure type, seizure frequency at diet onset, etiology, details regarding diet initiation, type of ketogenic formula, breastfeeding, route of administration, blood ketones, growth, length of NICU stay, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen infants younger than 12\u2009weeks of life who received KDT with a minimum follow\u2010up of 1\u2009month were included; 13 had early\u2010infantile developmental and epileptic encephalopathy, four epilepsy of infancy with migrating focal seizures, and two focal epilepsy. A &gt;50% response was observed in 73.7% at 1\u2009month on the diet; 37% achieved a\u2009&gt;\u200975% seizure reduction, and 10.5% became seizure free. At 3\u2009months, a &gt;50% decrease in seizure frequency was observed in 72.2%; 15.8% had a &gt;75% reduction; 21% became seizure free. Overall survival was 76% at 1\u2009year on diet. Incidence of acute and late adverse effects was low and most adverse effects were asymptomatic and manageable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our experience suggests that KDT is safe and effective in newborns and very young infants; however, further studies on the management of the diet in this vulnerable age group are necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12836","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T04:46:10Z","timestamp":1695876370000},"page":"138-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Use of ketogenic dietary therapy for drug\u2010resistant epilepsy in early infancy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-6380","authenticated-orcid":false,"given":"Marisa","family":"Armeno","sequence":"first","affiliation":[{"name":"Hospital de Pediatr\u00eda Prof. Dr. J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Calligaris","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Prof. Dr. J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gagiulo","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Prof. Dr. J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araceli","family":"Cresta","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Prof. Dr. J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Magdalena","family":"Vaccarezza","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Griselda","family":"Diez","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Julia","family":"Alberti","sequence":"additional","affiliation":[{"name":"Hospital Sor Maria Ludovica  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Viollaz","sequence":"additional","affiliation":[{"name":"Hospital Sor Maria Ludovica  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Vilavedra","sequence":"additional","affiliation":[{"name":"Hospital Sor Maria Ludovica  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-7743","authenticated-orcid":false,"given":"Roberto H.","family":"Caraballo","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Prof. Dr. J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.07.009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2021.106793"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13650"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2018.10.015"},{"issue":"10","key":"e_1_2_11_6_1","first-page":"305","article-title":"Tolerancia y respuesta a la terapia cetog\u00e9nica en neonatos y lactantes menores de 4 meses. 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