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Regions of interest (ROI) were defined based on the results of the second\u2010level analyses and activations within the predefined ROIs were compared across groups and correlated with postoperative verbal and nonverbal memory scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Healthy subjects showed activations within regions belonging to the dorsal visual stream and the PMN as well as the bilateral parahippocampal place area, the bilateral frontal eye field, and the bilateral middle frontal gyrus. Comparison between groups revealed that TLE patients activated significantly less in the left middle occipital gyrus and the right precuneus. The activation pattern in left TLE patients showed further reductions, mainly in areas belonging to the dorsal visual stream and the PMN within the left hemisphere. Activations within the left superior parietal lobulus, bilateral inferior parietal lobulus, bilateral middle temporal gyrus, left precuneus, left frontal eye field, and left middle frontal gyrus correlated significantly with postoperative verbal memory scores, and activations within the left superior parietal lobulus, left inferior parietal lobulus, left middle temporal gyrus, and left precuneus correlated significantly with higher performance in postoperative nonverbal memory scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The PMN is involved in episodic memory encoding. Higher activations in areas belonging to the PMN and the dorsal visual stream, especially within the left hemisphere, before amygdalohippocampectomy may result in higher postoperative memory scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain language summary<\/jats:title><jats:p>This study aims to investigate the effects of epilepsy due to hippocampal sclerosis, i.e. scarring in the temporal lobe, on memory networks in the brain. We discovered that especially patients with left\u2010sided hippocampal sclerosis show reduced brain activations in visual areas and memory networks within the left hemisphere of the brain during orientation in space. Importantly, higher activations within these areas may result in better memory after epilepsy surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12870","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T05:38:35Z","timestamp":1701236315000},"page":"287-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigating the effect of hippocampal sclerosis on parietal memory network"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-0531","authenticated-orcid":false,"given":"Silke","family":"Ethofer","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Milian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Erb","sequence":"additional","affiliation":[{"name":"Department of Biomedical Magnetic Resonance University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Rona","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Honegger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ethofer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Magnetic Resonance University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Psychiatry and Psychotherapy University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1607"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605719113"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.07.004"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00048.2006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(90)90061-R"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80474-2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70109-1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108023450501"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.42203.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000203623.02082.e3"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0032709"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_12_14_1","first-page":"21","article-title":"The Verbal Learning and Retention Test. 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