{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:45:32Z","timestamp":1789465532420,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BI 1254\/9\u20101"],"award-info":[{"award-number":["BI 1254\/9\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LA 3567\/2\u20101"],"award-info":[{"award-number":["LA 3567\/2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Neuroimaging studies reveal frontal lobe (FL) contributions to memory encoding. Accordingly, memory impairments are documented in frontal lobe epilepsy (FLE). Still, little is known about the structural or functional correlates of such impairments. Particularly, material specificity of functional changes in cerebral activity during memory encoding in FLE is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared 24 FLE patients (15 right\u2010sided) undergoing presurgical evaluation with 30 healthy controls on a memory fMRI\u2010paradigm of learning scenes, faces, and words followed by an out\u2010of\u2010scanner recognition task as well as regarding their mesial temporal lobe (mTL) volumes. We also addressed effects of FLE lateralization and performance level (normal vs. low).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FLE patients had poorer memory performance and larger left hippocampal volumes than controls. Volume increase seemed, however, irrelevant or even dysfunctional for memory performance. Further, functional changes in FLE patients were right\u2010sided for scenes and faces and bilateral for words. In detail, during face encoding, FLE patients had, regardless of their performance level, decreased mTL activation, while during scene and word encoding only low performing FLE patients had decreased mTL along with decreased FL activation. Intact verbal memory performance was associated with higher right frontal activation in FLE patients but not in controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Pharmacoresistant FLE has a distinct functional and structural impact on the mTL. Effects vary with the encoded material and patients' performance levels. Thus, in addition to the direct effect of the FL, memory impairment in FLE is presumably to a large part due to functional mTL changes triggered by disrupted FL networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>Frontal lobe epilepsy (FLE) patients may suffer from memory impairment. Therefore, we asked patients to perform a memory task while their brain was scanned by MRI in order to investigate possible changes in brain activation during learning. FLE patients showed changes in brain activation during learning and also structural changes in the mesial temporal lobe, which is a brain region especially relevant for learning but not the origin of the seizures in FLE. We conclude that FLE leads to widespread changes that contribute to FLE patients\u2019 memory impairment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12881","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:02:57Z","timestamp":1702544577000},"page":"355-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MRI evidence for material\u2010specific encoding deficits and mesial\u2013temporal alterations in presurgical frontal lobe epilepsy patients"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-0831","authenticated-orcid":false,"given":"Anna","family":"Doll","sequence":"first","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara) Medical School, Bielefeld University  Bielefeld Germany"},{"name":"Department of Psychology Bielefeld University  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8025-4075","authenticated-orcid":false,"given":"Martin","family":"Wegrzyn","sequence":"additional","affiliation":[{"name":"Department of Psychology Bielefeld University  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9502-0491","authenticated-orcid":false,"given":"Friedrich G.","family":"Woermann","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara) Medical School, Bielefeld University  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-8925","authenticated-orcid":false,"given":"Kirsten","family":"Labudda","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara) Medical School, Bielefeld University  Bielefeld Germany"},{"name":"Department of Psychology Bielefeld University  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-8654","authenticated-orcid":false,"given":"Christian G.","family":"Bien","sequence":"additional","affiliation":[{"name":"Department of Epileptology (Krankenhaus Mara) Medical School, Bielefeld University  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-1997","authenticated-orcid":false,"given":"Johanna","family":"Kissler","sequence":"additional","affiliation":[{"name":"Department of Psychology Bielefeld University  Bielefeld Germany"},{"name":"Center for Cognitive Interaction Technology (CITEC) Bielefeld University  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30220-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.07.017"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106538"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00454"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.02.028"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/7221"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0083-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03570.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.03.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12183"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03085.x"},{"key":"e_1_2_11_13_1","first-page":"3123","article-title":"Voxel based morphometry and manual volumetric analysis of the cingulate gyrus in patients with juvenile myoclonic epilepsy and frontal lobe epilepsy compared to normal controls","volume":"14","author":"Vu L","year":"2006","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/19714009211034839"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001461"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh293"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102723"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000078815.03224.57"},{"key":"e_1_2_11_20_1","first-page":"609","volume-title":"Surgical treatment of the epilepsies","author":"Engel J","year":"1993"},{"key":"e_1_2_11_21_1","volume-title":"Rey auditory verbal learning test: a handbook","author":"Schmidt M","year":"1996"},{"key":"e_1_2_11_22_1","volume-title":"Verbaler Lern\u2010 und Merkf\u00e4higkeitstest: VLMT; 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