{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:35:33Z","timestamp":1791322533122,"version":"4.3.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>New\u2010onset seizure\u2010like events (SLEs) are common in children, but differentiating between epilepsy and its mimics is challenging. This study provides an overview of the clinical characteristics, diagnoses, and corresponding etiologies of children evaluated at a first seizure clinic (FSC), which will be helpful for all physicians involved in the care of children with SLEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 1213 children who were referred to the FSC of a Dutch tertiary children's hospital over a 13\u2010year period and described their clinical characteristics, first routine EEG recording results, and the distribution and specification of their eventual epilepsy and non\u2010epilepsy diagnoses. The time interval to correct diagnosis and the diagnostic accuracy of the FSC were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u201cEpilepsy\u201d was eventually diagnosed in 407 children (33.5%), \u201cno epilepsy\u201d in 737 (60.8%), and the diagnosis remained \u201cunclear\u201d in 69 (5.7%). Epileptiform abnormalities were seen in 60.9% of the EEG recordings in the \u201cepilepsy\u201d group, and in 5.7% and 11.6% of the \u201cno epilepsy\u201d and \u201cunclear\u201d group, respectively. Of all children with final \u201cepilepsy\u201d and \u201cno epilepsy\u201d diagnoses, 68.6% already received their diagnosis at FSC consultation, and 2.9% of the children were initially misdiagnosed. The mean time to final diagnosis was 2.0\u2009months, and 91.3% of all children received their final diagnosis within 12\u2009months after the FSC consultation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We describe the largest pediatric FSC cohort to date, which can serve as a clinical frame of reference. The experience and expertise built at FSCs will improve and accelerate diagnosis in children with SLEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain language summary<\/jats:title><jats:p>Many children experience events that resemble but not necessarily are seizures. Distinguishing between seizures and seizure mimics is important but challenging. Specialized first\u2010seizure clinics can help with this. Here, we report data from 1213 children who were referred to the first seizure clinic of a Dutch children's hospital. One\u2010third of them were diagnosed with epilepsy. In 68.8% of all children\u2014with and without epilepsy\u2014the diagnosis was made during the first consultation. Less than 3% were misdiagnosed. This study may help physicians in what to expect regarding the diagnoses in children who present with events that resemble seizures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12883","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T20:38:55Z","timestamp":1702672735000},"page":"548-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical characteristics and diagnoses of 1213 children referred to a first seizure clinic"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3656-8795","authenticated-orcid":false,"given":"Geertruida","family":"Slinger","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center University Medical Center Utrecht and Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Noorlag","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center University Medical Center Utrecht and Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7773-1990","authenticated-orcid":false,"given":"Eric","family":"van Diessen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center University Medical Center Utrecht and Utrecht University  Utrecht The Netherlands"},{"name":"Department of Pediatrics, Franciscus Gasthuis &amp; Vlietland  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-6834","authenticated-orcid":false,"given":"Willem M.","family":"Otte","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center University Medical Center Utrecht and Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-5678","authenticated-orcid":false,"given":"Maeike","family":"Zijlmans","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center University Medical Center Utrecht and Utrecht University  Utrecht The Netherlands"},{"name":"Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-5668","authenticated-orcid":false,"given":"Floor E.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center University Medical Center Utrecht and Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-0003","authenticated-orcid":false,"given":"Kees P. J.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center University Medical Center Utrecht and Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503831"},{"key":"e_1_2_12_3_1","unstructured":"International League Against Epilepsy (ILAE).Epilepsy imitators. 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