{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:10:12Z","timestamp":1756728612280,"version":"3.44.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:00:00Z","timestamp":1705104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2005\/5464\u20109"],"award-info":[{"award-number":["2005\/5464\u20109"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between left epileptiform activity and language laterality indices (LI) in patients with right mesial temporal sclerosis (MTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two patients with right MTS and 22 healthy subjects underwent fMRI scanning while performing a language task. LI was calculated in multiple regions of interest (ROI). Data on the presence of left epileptiform abnormalities were obtained during prolonged video\u2010EEG monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After correction for multiple comparisons, LI was reduced in the middle temporal gyrus in the left interictal epileptiform discharges (IED+) group, compared with the left IED\u2212 group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Using a responsive reading naming fMRI paradigm, right MTS patients who presented left temporal interictal epileptiform abnormalities on video\u2010EEG showed decreased LI in the middle temporal gyrus, indicating decreased left middle temporal gyrus activation, increased right middle temporal gyrus activation or a combination of both, demonstrative of language network reorganization, specially in the MTG, in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>This research studied 22 patients with right mesial temporal sclerosis (a specific type of epilepsy) comparing them to 22 healthy individuals. Participants were asked to perform a language task while undergoing a special brain imaging technique (fMRI). The findings showed that patients with epilepsy displayed a change in the area of the brain typically responsible for language processing. This suggests that their brains may have adapted due to their condition, altering the way language is processed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12897","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T04:23:43Z","timestamp":1705119823000},"page":"626-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left\u2010sided epileptiform activity influences language lateralization in right mesial temporal sclerosis"],"prefix":"10.1002","volume":"9","author":[{"given":"Juliana Passos","family":"de Almeida","sequence":"first","affiliation":[{"name":"Department of Neurology, Epilepsy Program, Clinical Hospital University of Sao Paulo School of Medicine  Sao Paulo Brazil"},{"name":"LIM\u201044, Department of Radiology, Faculty of Medicine University of S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina Martins","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Epilepsy Program, Clinical Hospital University of Sao Paulo School of Medicine  Sao Paulo Brazil"},{"name":"LIM\u201044, Department of Radiology, Faculty of Medicine University of S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valmir","family":"Passarelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Epilepsy Program, Clinical Hospital University of Sao Paulo School of Medicine  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khallil Taverna","family":"Chaim","sequence":"additional","affiliation":[{"name":"LIM\u201044, Department of Radiology, Faculty of Medicine University of S\u00e3o Paulo  Sao Paulo 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