{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:43:13Z","timestamp":1791981793036,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Epileptic seizures occurring in late adulthood often remain of unknown origin. Sporadic cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease characterized by intracerebral hemorrhage, microhemorrhage and superficial siderosis, occurring mostly in elderly. This observational case\u2013control study aimed to assess the occurrence of CAA in patients experiencing their first seizure in late adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled consecutive patients aged \u226555\u2009years presenting with late\u2010onset seizures (LOS) to the emergency departments or outpatient clinics of two Italian centers, from April 2021 to October 2022. Two age\u2010matched control subjects with neurological symptoms other than epileptic seizure were recruited for each enrolled case. All participants underwent brain MRI (1.5 Tesla) including blood\u2010sensitive sequences and were assessed for probable CAA diagnosis according to Boston criteria 2.0. Chi\u2010squared test was performed to evaluate group differences. Univariate logistic regression analysis tested the association between clinical variables and CAA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 65 patients with LOS (27 females; mean age 72.2\u2009\u00b1\u20098.9\u2009years) and 130 controls (49 females; mean age 70.3\u2009\u00b1\u20098.9\u2009years). Diagnosis of probable CAA was achieved in 10.8% (7\/65) of LOS patients and 2.3% (3\/130) controls, with a statistically significant difference (<jats:italic>p<\/jats:italic>\u2009=\u20090.011). The OR for CAA in the LOS group was 5.2 as compared to the control group (95% CI\u2009=\u20091.3\u201320.6, <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The frequency of CAA is significatively higher in patients with LOS as compared to other neurological diseases, suggesting that a portion of LOS of unknown or vascular origin are associated with CAA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>Late\u2010onset seizures (LOS) are very frequent in the elderly and often have no clear cause. Cerebral amyloid angiopathy (CAA) is a condition where amyloid proteins build up in the blood vessels of the brain, causing them to become weak and prone to bleeding. In this study, we explored the occurrence of CAA in people with LOS. We found that people with LOS were more likely to have a diagnosis of CAA than controls (i.e., people with other neurological diseases).<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12976","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T14:54:22Z","timestamp":1720277662000},"page":"1723-1730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The hidden link between late\u2010onset seizures and cerebral amyloid angiopathy: A case\u2013control study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3735-7746","authenticated-orcid":false,"given":"Oreste","family":"Marsico","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Neurology Unit, Regional Epilepsy Centre Great Metropolitan \"Bianchi\u2010Melacrino\u2010Morelli\u201d Hospital  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-9494","authenticated-orcid":false,"given":"Angelo","family":"Pascarella","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Neurology Unit, Regional Epilepsy Centre Great Metropolitan \"Bianchi\u2010Melacrino\u2010Morelli\u201d Hospital  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-435X","authenticated-orcid":false,"given":"Sara","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Neurology Unit, Regional Epilepsy Centre Great Metropolitan \"Bianchi\u2010Melacrino\u2010Morelli\u201d Hospital  Reggio Calabria 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