{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:10:23Z","timestamp":1775041823116,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the Italian experience on the surgical and radiosurgical treatment of drug\u2010resistant epilepsy due to hypothalamic hamartoma (HH) in the period 2011\u20132021 in six Italian epilepsy surgery centers, and to compare safety and efficacy profiles of the different techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected pseudo\u2010anonymized patient's data with at least 12\u2009months of follow\u2010up. Surgical outcome was defined according to Engel classification of seizure outcome. Univariate analysis was performed to assess the risk of post\u2010operative seizures, categorized in dichotomous variable as favorable and unfavorable; explanatory variables were considered. Mann\u2013Whitney or Chi\u2010squared test were used to assess the presence of an association between variables (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Full presurgical and postoperative data about 42 patients from 6 epilepsy surgery centers were gathered. Engel class I was reached in the 65.8% and 66.6% of patients with gelastic and non\u2010gelastic seizures, respectively. Other than daily non\u2010gelastic seizures were associated with seizure freedom (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), and the radiological type presented a trend toward significance (<jats:italic>p<\/jats:italic>\u2009=\u20090.12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Endoscopic disconnection and laser interstitial thermal therapy are effective in the treatment of HH\u2010related epilepsy, with a tolerable safety profile. Both gelastic and non\u2010gelastic seizures can be treated, also in patients with a long history of seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>This study collected data about 42 patients with HH\u2010related epilepsies. Endoscopic disconnection and laser therapy are both effective and safe in the treatment of hypothalamic hamartoma\u2010related epilepsies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.12989","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:39:10Z","timestamp":1719448750000},"page":"1493-1501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surgical and radiosurgical treatment of hypothalamic hamartoma: The Italian experience between 2011 and 2021"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-6536","authenticated-orcid":false,"given":"Michele","family":"Rizzi","sequence":"first","affiliation":[{"name":"Functional Neurosurgery Unit, Department of Neurosurgery Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan 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