{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:28:16Z","timestamp":1767007696797,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSII5\u2010180365"],"award-info":[{"award-number":["CRSII5\u2010180365"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluates the performance of the novel MRI sequence stimulus\u2010induced rotary saturation (SIRS) to map responses to interictal epileptic activity in the human cortex. Spin\u2010lock pulses have been applied to indirectly detect neuronal activity through magnetic field perturbations. Following initial reports about the feasibility of the method in humans and animals with epilepsy, we aimed to investigate the diagnostic yield of spin\u2010lock MR pulses in comparison with scalp\u2010EEG in first seizure patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed a novel method for measurements of neuronal activity through the detection of a resonant oscillating field, stimulus\u2010induced rotary saturation contrast (SIRS) at spin\u2010lock frequencies of 120 and 240\u2009Hz acquired at a single 3T MRI system. Within a prospective observational study, we conducted SIRS experiments in 55 patients within 7\u2009days after a suspected first unprovoked epileptic seizure and 61 healthy control subjects. In this study, we report on the analysis of data from a single 3T MRI system, encompassing 35 first seizure patients and 31 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SIRS method was applicable in all patients and healthy controls at frequencies of 120 and 240\u2009Hz. We did not observe any significant age\u2010 or sex\u2010related differences. Specificity of SIRS at 120\u2009Hz was 90.3% and 93.5% at 240\u2009Hz. Sensitivity was 17.1% at 120\u2009Hz and 40.0% at 240\u2009Hz.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>SIRS targets neuronal oscillating magnetic fields in patients with epilepsy. The coupling of presaturated spins to epilepsy\u2010related magnetic field perturbations may serve as a\u2014at this stage experimental\u2014diagnostic test in first seizure patients to complement EEG findings as a standard screening test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>Routine diagnostic tests carry several limitations when applied after a suspected first seizure. SIRS is a noninvasive MRI method to enable time\u2010sensitive diagnosis of image correlates of epileptic activity with increased sensitivity compared to routine EEG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.13001","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T15:48:26Z","timestamp":1720280906000},"page":"1745-1757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuronal current imaging of epileptic activity: An MRI study in patients with a first unprovoked epileptic seizure"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1497-2615","authenticated-orcid":false,"given":"Baudouin Zongxin","family":"Jin","sequence":"first","affiliation":[{"name":"Support Center of Advanced Neuroimaging, Institute of Diagnostic and Interventional Neuroradiology Inselspital  Bern Switzerland"},{"name":"Sleep\u2010Wake\u2010Epilepsy\u2010Center, Department of Neurology Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Graduate School of Health Sciences, Medical Faculty University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Capiglioni","sequence":"additional","affiliation":[{"name":"Support Center of Advanced Neuroimaging, Institute of Diagnostic and Interventional Neuroradiology Inselspital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Federspiel","sequence":"additional","affiliation":[{"name":"Support Center of Advanced Neuroimaging, Institute of Diagnostic and Interventional Neuroradiology Inselspital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uzeyir","family":"Ahmadli","sequence":"additional","affiliation":[{"name":"Support Center of Advanced Neuroimaging, Institute of Diagnostic and Interventional Neuroradiology Inselspital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2387-7767","authenticated-orcid":false,"given":"Kaspar","family":"Schindler","sequence":"additional","affiliation":[{"name":"Sleep\u2010Wake\u2010Epilepsy\u2010Center, Department of Neurology Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Support Center of Advanced Neuroimaging, Institute of Diagnostic and Interventional Neuroradiology Inselspital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Wiest","sequence":"additional","affiliation":[{"name":"Support Center of Advanced Neuroimaging, Institute of Diagnostic and Interventional Neuroradiology Inselspital  Bern Switzerland"},{"name":"Swiss Institute for Translational and Entrepreneurial Medicine Sitem\u2010Insel  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"475","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher RS","year":"2014","journal-title":"Sci Direct"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12739"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200304000-00008"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000473351.32413.7c"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.7.965"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12375"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12543"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad047"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04356-x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.001"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx241"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016150368"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16270"},{"key":"e_1_2_14_15_1","unstructured":"CapiglioniM TurcoF WiestR KieferC.SIRS sequence as frequency filter: a simulation and phantom study of spin\u2010lock preparations among composite signals. 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