{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:17:02Z","timestamp":1781777822974,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess antiseizure effects of cenobamate, a new antiseizure medication with at least two mechanisms of action, in the rare, highly pharmacoresistant and progressive epilepsy syndrome related to Rasmussen's encephalitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three patients from the epilepsy centers in Freiburg, Kork, and Valencia are reported with focal epilepsy which had been pharmacoresistant to more than 10 prior treatment regimens. Assessment included at least 1\u2009year of follow\u2010up after cenobamate introduction and included seizure frequency, seizure severity (in particular status epilepticus) and changes in co\u2010medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the three patients, cenobamate add on treatment proved superior to all prior antiseizure and immunomodulatory treatments which had been individually applied. Not only were focal to bilateral tonic\u2013clonic seizure completely controlled, but also focal motor status epilepticus no longer occurred. Co\u2010medication could be reduced in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This case series in a rare and highly pharmacoresistant epilepsy syndrome suggests high efficacy of cenobamate add\u2010on treatment for seizure control. This may be a valuable information in epilepsy related to Rasmussen encephalitis and calls for further elucidation of the mechanism involved in superior seizure control also compared to prior treatments including sodium channel blockers and benzodiazepines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>Rasmussen's encephalitis is a rare type of epilepsy that gets worse over time and doesn't respond well to most seizure medications. We describe three patients who tried many treatments without much success, but when they added cenobamate to their treatment, it worked better than the other medications. This also let them lower the overall amount of medication they were taking.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.13060","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T16:39:47Z","timestamp":1728578387000},"page":"2537-2545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of add\u2010on Cenobamate treatment in refractory epilepsy due to Rasmussen's encephalitis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-0506","authenticated-orcid":false,"given":"Andres","family":"Schulze\u2010Bonhage","sequence":"first","affiliation":[{"name":"Epilepsy Center University Medical Center, University of Freiburg  Freiburg Germany"},{"name":"European Reference Network EpiCare  Europe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-5862","authenticated-orcid":false,"given":"Bernhard","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Department for Adults Kork Epilepsy Center  Kehl\u2010Kork Germany"},{"name":"Medical Faculty University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Garc\u00e9s","sequence":"additional","affiliation":[{"name":"Multidisciplinary Epilepsy Unit University Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4496-1458","authenticated-orcid":false,"given":"Martin","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Epilepsy Center University Medical Center, University of Freiburg  Freiburg Germany"},{"name":"European Reference Network EpiCare  Europe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-8042","authenticated-orcid":false,"given":"Vicente","family":"Villanueva","sequence":"additional","affiliation":[{"name":"European Reference Network EpiCare  Europe"},{"name":"Multidisciplinary Epilepsy Unit University Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"14","article-title":"Prevalence and clinical outcome of Rasmussen encephalitis in children from the United Kingdom","volume":"55","author":"Lamb K","year":"2013","journal-title":"Dev Med Child Neurol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh415"},{"key":"e_1_2_8_4_1","first-page":"7","volume-title":"Chronic encephalitis and epilepsy. 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