{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:50:09Z","timestamp":1742385009125,"version":"3.37.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Intracerebral hemorrhages (ICH) during implantation of stereo\u2010EEG electrodes are rare. The impact of tobacco\u2010free nicotine consumption on periprocedural bleeding is uncertain. We present a 20+ year\u2010old man with drug\u2010resistant epilepsy who underwent stereo\u2010EEG with 17 depth electrodes. Within a few days after insertion, the patient developed multiple ICHs in the electrode trajectories and an intradural hemorrhage after a diagnostic spinal tap. We performed the investigation of the clotting system and whole\u2010exome sequencing (WES). WES identified a heterozygous mutation c.4698G&gt;T, p.(Trp1566Cys) in <jats:italic>COL4A2<\/jats:italic> (NM_001846.4) encoding a collagen type\u2010IV alpha\u20102 chain inherited from his seemingly healthy mother. As <jats:italic>COL4A2<\/jats:italic> mutations had been identified in four adult patients with ICH we postulated that the identified variant presents a potential risk factor. Notably, mutations encoding other collagens have been linked to cerebral hemorrhages (<jats:italic>COL4A1<\/jats:italic>) and increased propensity to trigger ICH upon smoking (<jats:italic>COL1A2<\/jats:italic>). Our patient consumed at least 24 oral nicotine pouches (containing 11\u2009mg nicotine each) per day. We consider the patient's <jats:italic>COL4A2<\/jats:italic> mutation in combination with his substantial nicotine consumption as likely predisposition to multiple ICHs precipitated by stereo\u2010EEG. Patients with nicotine consumption and any collagen mutation may have a substantially higher risk for hemorrhagic complications in SEEG and other neurosurgical procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>A young man with drug\u2010resistant epilepsy experienced multiple intracerebral hemorrhages after implantation of SEEG electrodes for presurgical evaluation and concomitantly a intradural hemorrhage after a lumbar spinal tap. A collagen IV mutation of unclear significance and heavy use of oral nicotine pouches were the only potential risk factors identified. As collagen mutations were previously described risk factors and smoking in particular worsens the bleeding risk in collagen mutations, further research is warranted to prevent hemorrhages in neurosurgical procedures. Nicotine consumption in any form is a preventable risk factor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.13102","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T11:44:47Z","timestamp":1732362287000},"page":"329-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple intracerebral hematomas during <scp>SEEG<\/scp> recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen <scp>IV<\/scp> gene mutation and oral nicotine consumption as risk factors"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-6762","authenticated-orcid":false,"given":"Markus","family":"Leitinger","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurocritical Care, and Neurorehabilitation, Center for Cognitive Neuroscience, European Reference Network EpiCARE, Christian Doppler University Hospital Paracelsus Medical University  Salzburg Austria"},{"name":"Neuroscience Institute, Center for Cognitive Neuroscience, Christian Doppler University Hospital Paracelsus Medical University  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-9772","authenticated-orcid":false,"given":"Serena","family":"Broggi","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit ASST Sette Laghi Hospital  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Spendel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Christian Doppler University Hospital Paracelsus Medical University  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4311-1734","authenticated-orcid":false,"given":"Gudrun","family":"Kalss","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical 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Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Rossini","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical Care, and Neurorehabilitation, Center for Cognitive Neuroscience, European Reference Network EpiCARE, Christian Doppler University Hospital Paracelsus Medical University  Salzburg Austria"},{"name":"Neuroscience Institute, Center for Cognitive Neuroscience, Christian Doppler University Hospital Paracelsus Medical University  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7593-0056","authenticated-orcid":false,"given":"Julia","family":"H\u00f6fler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical Care, and Neurorehabilitation, Center for Cognitive Neuroscience, European Reference Network EpiCARE, Christian Doppler University Hospital Paracelsus Medical University  Salzburg 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