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However, the development and reliability of intrinsic brain networks in the early period of epileptogenesis are not well understood. The current study aims to fill this gap by investigating the test\u2013retest reliability of intrinsic brain networks in the early stage of epileptogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the rat intrahippocampal kainic acid model of mesial temporal lobe epilepsy. Three sessions of resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) data were acquired over a 2\u2010week period from 9 sham control rats and 12 rats that later developed spontaneous epilepsy (KA). A group independent component analysis (GICA) approach was used to identify the intrinsic brain networks. Both within and between networks were identified, and test\u2013retest reliability was assessed using the intraclass correlation coefficient (ICC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed good\u2010to\u2010excellent within\u2010network stability of resting\u2010state functional brain connectivity in most intrinsic brain networks in sham control rats and in the KA group, except for frontal cortex (FCN) and hippocampal networks (HPN). Further analysis of the between networks showed an increase in variation in the KA brain compared to the sham controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Overall, our study demonstrated a \u201cmoderately stable\u201d phase of the intrinsic brain network in a 2\u2010week latent period window, with an altered between\u2010 and within\u2010network connectome feature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>This fMRI study explored how brain connectivity changes in healthy animals compared to animals in the latent period of epilepsy. We found that functional connectivity increased during the latent period compared to the control group, and this increase persisted across all tested sessions. Additionally, brain networks became less stable in the epilepsy group, particularly in the frontal cortex and hippocampus. These observations provide further insight into how brain networks change and persist during the early stages of epileptogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.70002","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:34:27Z","timestamp":1740047667000},"page":"508-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intrinsic brain network stability during kainic acid\u2010induced epileptogenesis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-2898","authenticated-orcid":false,"given":"Nastaran","family":"Jafari","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of North Texas  Denton Texas 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