{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:52:23Z","timestamp":1783155143317,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K13709"],"award-info":[{"award-number":["JP21K13709"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012628","name":"Japan Epilepsy Research Foundation","doi-asserted-by":"publisher","award":["TENKAN 23006"],"award-info":[{"award-number":["TENKAN 23006"]}],"id":[{"id":"10.13039\/501100012628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Effective epilepsy management requires accurate epilepsy knowledge, active patient engagement, and stigma reduction to improve health outcomes. Educational interventions have been shown to enhance patients' quality of life (QOL) and knowledge. This study evaluated the effectiveness of EpiloBot, an artificial intelligence (AI)\u2010powered chatbot designed to provide epilepsy education and psychosocial support, through a pre\u2010post intervention study measuring changes in knowledge, attitudes, and self\u2010stigma among people with epilepsy (PWE) and their supporters (including caregivers, family members, friends, or others closely involved with someone with epilepsy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study consisted of two phases: a preliminary pretest phase to refine chatbot content and a main intervention phase. In the main phase, 176 participants (13 PWE, 69 active supporters, 28 potential future supporters, and 66 others) registered to use EpiloBot via the smartphone app. Of these, 82 completed both pre\u2010 and post\u2010intervention surveys. The surveys assessed epilepsy\u2010related knowledge, workplace attitudes, and self\u2010stigma before and after chatbot use. Paired t\u2010tests and Wilcoxon signed\u2010rank tests were used to analyze changes over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The chatbot intervention led to a significant improvement in attitudes toward workplace equality for PWE (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and in knowledge about epilepsy treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.022). A slight increase in epilepsy\u2010related self\u2010stigma was observed among participants with epilepsy (<jats:italic>n<\/jats:italic>\u2009=\u20099, <jats:italic>p<\/jats:italic>\u2009=\u20090.022). Non\u2010significant results were removed to streamline the findings. These results highlight the chatbot's potential as a scalable digital tool for epilepsy education and psychosocial support, although the challenge of addressing self\u2010stigma remains a critical issue for future applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>EpiloBot demonstrates effectiveness in enhancing epilepsy\u2010related knowledge and workplace attitudes but also reveals the complexities of self\u2010stigma dynamics. While educational interventions can promote inclusivity and knowledge gain, self\u2010stigma may increase due to heightened awareness of epilepsy\u2010related challenges. Future studies should explore long\u2010term impacts, integrating educational and psychosocial support interventions to optimize chatbot\u2010based learning in epilepsy care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Plain Language Summary<\/jats:title><jats:p>This study tested EpiloBot, an AI\u2010powered chatbot designed to educate people with epilepsy (PWE) and their supporters, including caregivers and family members. We measured changes in epilepsy\u2010related knowledge, attitudes, and self\u2010stigma before and after chatbot use. Results showed improved attitudes toward PWE in the workplace and increased understanding of epilepsy treatment. However, self\u2010stigma slightly increased among PWE, possibly due to greater awareness of social challenges, highlighting the need for long\u2010term psychosocial support alongside education.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epi4.70095","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T16:39:33Z","timestamp":1753720773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating the impact of an <scp>AI<\/scp>\u2010powered chatbot on epilepsy education and stigma reduction: A pre\u2010post intervention study using <scp>EpiloBot<\/scp>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-5213","authenticated-orcid":false,"given":"Izumi","family":"Kuramochi","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Saitama Medical Center Saitama Medical University  Saitama Japan"},{"name":"National Center of Neurology and Psychiatry, 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