{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:09:17Z","timestamp":1778936957168,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["PR2022\u20100117"],"award-info":[{"award-number":["PR2022\u20100117"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate a recently developed MRI technique for mapping the Mean Diffusivity of Tissue (MDT), which improves diffusion MRI imaging of the cerebral cortex by reducing partial volume effects from cerebrospinal fluid (CSF). As cortical lesions are common in patients with focal epilepsy, we explored the clinical value of MDT imaging in patients with drug resistant epilepsy and low\u2010grade glioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This is a prospective study in which 18 patients undergoing evaluation for epilepsy surgery and five patients undergoing evaluation for low\u2010grade glioma were recruited. Patients underwent conventional MRI and MDT imaging. The images were analyzed by a neuroradiologist who visually assessed the images using a lesion visibility score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elevated MDT coincided with suspected FLAIR\u2010positive FCD lesions in the majority of cases (5 out of 8 lesions). Ulegyria was also MDT\u2010positive, but heterotopias were not. MDT did not detect abnormalities in epilepsy surgery cases previously deemed MRI\u2010negative. In low\u2010grade gliomas, MDT and FLAIR findings were co\u2010localized; however, the MDT abnormalities were more conspicuous, and tumor\u2010associated signals were more distinct relative to FLAIR. MDT was helpful in visual demarcation of ischemia and glioma tumor\u2010associated signals in postoperative imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content>\n                      frequently aligns with the FLAIR signal, but MDT is visually more prominent. In the presurgical evaluation of epilepsy patients, it contributes to supporting existing or ambiguous findings. The very pronounced MDT signal in low\u2010grade gliomas might have the potential to be a visual aid in the diagnosis, treatment, and follow\u2010up of low\u2010grade gliomas.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>This is a pilot study that investigates a newly developed MRI technique called MDT imaging. The study shows that MDT helps identify brain lesions in patients with epilepsy. Finding brain lesions can improve the success of epilepsy surgery and help patients become seizure\u2010free. MDT imaging also helps visualize tumors in low\u2010grade glioma patients, which could improve surgical planning. These early findings suggest that MDT could be an additional useful tool for imaging in epilepsy surgery and low\u2010grade glioma patients, but more research is required to confirm its benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi4.70244","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:20:46Z","timestamp":1772961646000},"page":"592-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microstructure imaging in patients undergoing evaluation for epilepsy surgery or low\u2010grade glioma: Clinical utility of a novel diffusion\n                    <scp>MRI<\/scp>\n                    method"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-2516","authenticated-orcid":false,"given":"Irena","family":"Grubor","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Skane University Hospital and Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Serednicka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Skane University Hospital and Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"S\u00e4ll","sequence":"additional","affiliation":[{"name":"Medical Radiation Physics, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Diagnostic Radiology, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Compagno","family":"Strandberg","sequence":"additional","affiliation":[{"name":"Division of Neurology, Skane University Hospital and Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Medical Radiation Physics, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Diagnostic Radiology, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Bengzon","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Skane University Hospital and Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.02.007"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2020.04.001"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2020.1174"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010015\u20101500\u20101"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.082"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30552"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.039"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.109007"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2015.10.012"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118673"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.08.016"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1053\u20108119(03)00336\u20107"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216399120"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.3.617"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17333"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2511081092"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16451"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12143"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24662"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18567"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13311"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013\u20109580.2004.04014.x"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.08.013"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2008.01970.x"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730\u2010725x(94)92027\u20103"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads8149"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13441"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010013\u20102677\u20102"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt345"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010022\u201004139\u20109"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030424"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00550"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109405"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1514"}],"container-title":["Epilepsia 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