{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:15:12Z","timestamp":1780481712868,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2026,6]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n First seizure events are common and may exert an immediate and profound impact on people's lives. Less understood are their long\u2010term consequences. This prospective, longitudinal study aimed to measure and compare psychosocial and health\u2010related work productivity trajectories following first seizure events of various etiologies.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Adults with first seizure events were recruited from five epilepsy centers in Australia and the US between 2020 and 2023. Participants completed questionnaires covering health\u2010related quality of life (HRQOL; EQ\u20105D\u20105L, QOLIE\u201031), anxiety and depressive symptomatology (HADS), and productivity (WPAI) within 6\u2009weeks of their first seizure event, and 6\u2010 and 12\u2009months later.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred ninety\u2010six participants (median age 42\u2009years, 55.6% male) met inclusion criteria. 101 (51.5%) had newly\u2010diagnosed epilepsy, 46 (23.4%) had acute symptomatic seizures, and 49 (25.0%) had syncope (seizure mimic). Compared to baseline, at 12\u2010month follow\u2010up, the acute symptomatic seizure group showed significant improvement in EQ\u20105D\u20105L utility (\n p<\/jats:italic>\n \u2009=\u20090.001). The newly diagnosed epilepsy and acute symptomatic seizure groups both demonstrated improved QOLIE\u201031 scores over 12\u2009months (acute symptomatic seizure\n p<\/jats:italic>\n \u2009=\u20090.025; newly diagnosed epilepsy\n p<\/jats:italic>\n \u2009<\u20090.001). The newly diagnosed epilepsy group showed significant reductions in absenteeism (\n p<\/jats:italic>\n \u2009<\u20090.001), presenteeism (\n p<\/jats:italic>\n \u2009<\u20090.001), overall work impairment (\n p<\/jats:italic>\n \u2009<\u20090.001), and activity impairment (\n p<\/jats:italic>\n \u2009=\u20090.002). The acute symptomatic seizure group had a significant reduction in informal care needs (\n p<\/jats:italic>\n \u2009<\u20090.001). Anxiety and depressive symptomatology remained unchanged across all groups.\n <\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n HRQOL improved for people with acute symptomatic seizures and newly diagnosed epilepsy over time, but anxiety and depressive symptomatology remained unchanged. Future studies may explore interventions to improve screening and treatment of anxiety and depression for people following first seizure events.<\/jats:p>\n <\/jats:sec>\n \n Plain Language Summary<\/jats:title>\n This study investigated changes in quality of life, anxiety and depressive symptomatology, and health\u2010related work productivity over a 12\u2010month period for adults with first seizure events. Participants reported improvements in quality of life, reduced sick days, increased productivity at work, and less need for informal care. Concerningly, there was no change in their anxiety and depressive symptoms. The findings of this study may prompt first seizure clinicians to regularly screen patients for anxiety and depressive disorders, and treat these appropriately.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/epi4.70249","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:34:32Z","timestamp":1773495272000},"page":"859-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trajectories of quality of life, anxiety and depressive symptomatology, and health\u2010related work productivity after first seizure events"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-3844","authenticated-orcid":false,"given":"Emma","family":"Foster","sequence":"first","affiliation":[{"name":"Department of Neuroscience, School of Translational Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital Parkville 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Yong","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Translational Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital Parkville Victoria Australia"},{"name":"Department of Neurology Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-6475","authenticated-orcid":false,"given":"John\u2010Paul","family":"Nicolo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, School of Translational Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital Parkville Victoria Australia"},{"name":"Department of Neurology Alfred Health Melbourne Victoria 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