{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:15:13Z","timestamp":1780481713417,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43 TW009337"],"award-info":[{"award-number":["D43 TW009337"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43 TW011949"],"award-info":[{"award-number":["D43 TW011949"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["R01 NS118483"],"award-info":[{"award-number":["R01 NS118483"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Convulsive status epilepticus (CSE) is a major neurological emergency in childhood, but population\u2010based data from low\u2010 and middle\u2010income countries remain limited. We estimated the incidence, mortality, neurological outcomes, and predictors of adverse outcomes among children with CSE in Kano, northern Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a review of one\u2010year surveillance data on childhood CSE across eight hospitals and a random sample of eight primary health centers in the Kano metropolis. Cases were identified using standardized definitions and weighted to account for sampling at primary health centers. Demographic and clinical data were collected at presentation and during hospitalization. Logistic regression analysis was used to identify predictors of mortality and new\u2010onset neurological deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 972 children with CSE were identified at participating hospitals, with additional cases detected at primary health centers. After weighting, an estimated 1921 CSE cases occurred during the study period, corresponding to an annual incidence of 98 per 100\u2009000 children aged 1\u2009month\u201314\u2009years. Incidence was highest among infants (175 per 100\u2009000). Among hospitalized children, in\u2010hospital mortality was 24.7%, with more than half of the deaths occurring within 24\u2009h of admission. New\u2010onset neurologic deficits were observed in 9.6% of hospitalized survivors. In multivariable analysis, hypoglycemia at presentation, presumed meningoencephalitis, and CSE lasting longer than 30\u2009min were independently associated with increased odds of death. Neurological deficits were associated with multiple CSE episodes, prolonged seizures, and presumed meningoencephalitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Childhood CSE in Kano is associated with a high incidence and substantial mortality, particularly among infants. Hypoglycemia, central nervous system infections, and prolonged seizures are key predictors of adverse outcomes. These findings highlight the need for improved early recognition and strengthened emergency seizure management in resource\u2010limited settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Convulsive status epilepticus is a dangerous type of prolonged seizure in children. In this study from Kano, Nigeria, many children developed this condition and about one in four hospitalized patients died. Low blood sugar, suspected brain infections, and long seizures increased the risk of poor outcomes. Improving early treatment and emergency care may help reduce these deaths.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi4.70265","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:59:42Z","timestamp":1775750382000},"page":"973-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and outcomes of childhood status epilepticus in Kano, northern Nigeria"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-1198","authenticated-orcid":false,"given":"Umar A.","family":"Sabo","sequence":"first","affiliation":[{"name":"Department of Paediatrics Bayero University  Kano Nigeria"},{"name":"Department of Paediatrics Aminu Kano Teaching Hospital  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Bayero University  Kano Nigeria"},{"name":"Department of Paediatrics Aminu Kano Teaching Hospital  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminu T.","family":"Abdullahi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Aminu Kano Teaching Hospital and Bayero University  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Adamu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Aminu Kano Teaching Hospital  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auwal S.","family":"Salihu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Aminu Kano Teaching Hospital and Bayero University  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abba M.","family":"Abdullahi","sequence":"additional","affiliation":[{"name":"Hasiya Bayero Paediatric Hospital  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminu","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Aminu Kano Teaching Hospital  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubairu","family":"Iliyasu","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Aminu Kano Teaching Hospital and Bayero University Kano  Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamilu","family":"Zakari","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Murtala Mohammed Specialist Hospital  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safiya","family":"Gambo","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Murtala Mohammed Specialist Hospital  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binta W.","family":"Jibir","sequence":"additional","affiliation":[{"name":"Hasiya Bayero Paediatric Hospital  Kano Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muktar H.","family":"Aliyu","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Global Health Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Health Policy Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman J.","family":"Wudil","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Global Health Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J.","family":"Ingles","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Global Health Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather L.","family":"Prigmore","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Global Health Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan E.","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Global Health Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela R.","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Global Health Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2370-5970","authenticated-orcid":false,"given":"Edwin","family":"Trevathan","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Global Health Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.08.021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14729"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70331-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4314\/bajopas.v9i1.14"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2019.100362"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-022-04301-8"},{"key":"e_1_2_11_10_1","unstructured":"Commission NP.Projected Kano Metropolitan LGAs Population 2018. 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