{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:56Z","timestamp":1792471136594,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aimed to assess long\u2010term memory outcomes in patients with temporal lobe epilepsy (\n                      <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>\n                      ) who underwent anterior temporal lobectomy (\n                      <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>\n                      ) or selective amygdalohippocampectomy (\n                      <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>\n                      ), compared to nonoperated\n                      <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>\n                      over a 10\u2010year follow\u2010up period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 48 participants were studied: 10\n                      <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>\n                      , 26\n                      <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>\n                      , and 12 patients with nonoperated mesial temporal lobe epilepsy (\n                      <jats:styled-content style=\"fixed-case\">MTLE<\/jats:styled-content>\n                      ). Verbal memory was assessed using the S\u00f6zel Bellek S\u00fcre\u00e7leri Testi (\n                      <jats:styled-content style=\"fixed-case\">SBST<\/jats:styled-content>\n                      \u2014a test of verbal memory processes), and nonverbal memory was evaluated with the Wechsler memory scale\u2014visual reproduction (\n                      <jats:styled-content style=\"fixed-case\">WMS<\/jats:styled-content>\n                      ) (Turkish adaptation). Given the small and unbalanced groups, linear mixed\u2010effects models (\n                      <jats:styled-content style=\"fixed-case\">LMMs<\/jats:styled-content>\n                      ) were used as the primary inferential analyses to test group \u00d7 time interactions. Statistically reliable individual changes were identified using the reliable change index (\n                      <jats:styled-content style=\"fixed-case\">RCI<\/jats:styled-content>\n                      ). Neuropsychological outcomes were analyzed longitudinally over a 10\u2010year follow\u2010up period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant group \u00d7 time interaction was observed for verbal total learning (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The nonoperated TLE group showed a significant decline over time, whereas both surgical groups differed significantly from it. The ATL group demonstrated significant improvement. For delayed verbal recall, a significant main effect of group was observed; however, the group \u00d7 time interaction was not statistically significant. Visual immediate recall showed a significant group \u00d7 time interaction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), with a significant interaction effect in the ATL group. Visual delayed recall demonstrated a significant group \u00d7 time interaction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with significant interaction effects in both surgical groups. Seizure freedom was achieved in 90% of ATL and 80% of SAH cases; however, seizure outcome was not significantly associated with memory outcomes. Reliable change index analyses indicated lateralization\u2010dependent patterns of change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>ATL, particularly left\u2010sided ATL, was associated with statistically significant long\u2010term improvements in verbal memory and significant longitudinal changes in visual memory. SAH demonstrated significant longitudinal effects in selected memory domains. In contrast, nonoperated TLE patients showed significant cognitive decline over time. These findings highlight differential long\u2010term cognitive trajectories across treatment approaches and the role of lateralization in memory outcomes following epilepsy surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>\n                      We examined memory changes over 10\u2009years in people with temporal lobe epilepsy who underwent different surgical treatments or received medical management alone. Patients who underwent anterior temporal lobectomy (\n                      <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>\n                      ), particularly on the left side, showed improvement in certain memory measures over time. Those who had selective amygdalohippocampectomy (\n                      <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>\n                      ) demonstrated more domain\u2010specific cognitive changes despite good seizure control. In contrast, patients who did not undergo surgery experienced a decline in verbal learning. These findings suggest that surgical approach and brain lateralization play important roles in long\u2010term memory outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi4.70295","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T06:40:21Z","timestamp":1784443221000},"page":"1502-1512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ten\u2010year cognitive outcomes following epilepsy surgery: Temporal lobectomy versus selective amygdalohippocampectomy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-941X","authenticated-orcid":false,"given":"Tehran","family":"Aliyeva","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-8381","authenticated-orcid":false,"given":"Fadime \u00c7ad\u0131rc\u0131","family":"Tunga\u00e7","sequence":"additional","affiliation":[{"name":"Brain and Cognition Research Center, BEYKOG Istanbul Medipol University  Istanbul Turkey"},{"name":"Vocational School, Program of Electroneurophysiology Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8451-7650","authenticated-orcid":false,"given":"Beyza","family":"Tagraf","sequence":"additional","affiliation":[{"name":"Brain and Cognition Research Center, BEYKOG Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-1838","authenticated-orcid":false,"given":"\u00c7igdem","family":"Ozkara","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Cerrahpa\u015fa University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-5639","authenticated-orcid":false,"given":"Mustafa","family":"Uzan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine Cerrahpa\u015fa University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4292-5717","authenticated-orcid":false,"given":"Lutfu","family":"Hanoglu","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Istanbul Medipol University  Istanbul Turkey"},{"name":"Brain and Cognition Research Center, BEYKOG Istanbul Medipol University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"609","article-title":"Surgical treatment of the epilepsies","volume":"55","author":"Engel J","year":"2013","journal-title":"Contemp Neurol Ser"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.09.012"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528\u20101157.2002.49901.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.3"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013\u20109580.2004.23304.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.3.JNS192624"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.JNS09677"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2013.0587"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106596"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2011.03022.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.04.028"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12168"},{"issue":"2","key":"e_1_2_13_14_1","first-page":"99","article-title":"Cognitive recovery patterns in mesial temporal lobe epilepsy: a neuroimaging study","volume":"10","author":"Hano\u011flu L","year":"2004","journal-title":"J Clin Neurol"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18147"},{"key":"e_1_2_13_16_1","first-page":"196","article-title":"S\u00f6zel Bellek S\u00fcre\u00e7leri Testi (SBST)","volume":"29","author":"\u00d6ktem \u00d6","year":"1992","journal-title":"Noropsikiyatr Ars"},{"key":"e_1_2_13_17_1","unstructured":"Karaka\u015fS EskiR Ba\u015farE.T\u00fcrk k\u00fclt\u00fcr\u00fc i\u00e7in standardizasyonu yap\u0131lm\u0131\u015f n\u00f6ropsikolojik testler toplulu\u011fu. 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