{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:04:49Z","timestamp":1790352289850,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L256053"],"award-info":[{"award-number":["L256053"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the comparative cost\u2010effectiveness of anterior temporal lobectomy (ATL) and magnetic resonance\u2013guided laser interstitial thermal therapy (LITT) in patients with drug\u2010resistant mesial temporal lobe epilepsy (mTLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A decision\u2010analytic model was constructed to simulate the risks, benefits, and costs of ATL versus LITT over a 1\u2010year time horizon from a healthcare system perspective. Model inputs, including seizure freedom rates, complication probabilities, and cost estimates, were derived from recent meta\u2010analyses and published cost comparison studies. The main outcome measure was the probability of a positive outcome, which was defined as seizure freedom without major complication. Incremental cost\u2010effectiveness ratios (ICERs) were calculated, and both one\u2010way and two\u2010way sensitivity analyses were conducted to assess parameter uncertainty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the base\u2010case analysis, ATL achieved a 61% probability of a positive outcome compared with 55% for LITT. The mean per\u2010patient cost was $145\u2009847 for ATL and $108\u2009730 for LITT, resulting in an incremental cost of $37\u2009117. Although ATL provided a modest 6% absolute increase in favorable outcomes, the ICER was $574\u2009521 per additional positive outcome gained relative to LITT. Sensitivity analyses demonstrated that LITT remained the more cost\u2010effective option under most plausible parameter values, with ATL becoming favorable only under conditions of unusually high seizure freedom and low complication rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Although ATL yields slightly superior seizure outcomes, its substantially higher costs render LITT the more cost\u2010effective strategy for drug\u2010resistant mTLE at a 1\u2010year horizon. These findings support the growing role of minimally invasive techniques in epilepsy surgery, though further real\u2010world and long\u2010term data are needed to confirm the durability of LITT's clinical and economic benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>This study compared two surgical treatments for drug\u2010resistant mesial temporal lobe epilepsy: anterior temporal lobectomy (ATL) and laser interstitial thermal therapy (LITT). Using a decision\u2010analytic model over 1 year, ATL showed slightly better seizure outcomes but at a substantially higher cost. Overall, LITT was more cost\u2010effective in most scenarios due to lower costs and fewer complications. These findings suggest that LITT may offer a practical and economically favorable option for many patients, although treatment decisions should still consider individual clinical factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi4.70302","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:20:41Z","timestamp":1790349641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010effectiveness of laser interstitial thermal therapy vs. anterior temporal lobectomy for drug\u2010resistant mesial temporal lobe epilepsy: A decision analytic model"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-1337","authenticated-orcid":false,"given":"Zhihao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"International Neuroscience Institute (China\u2010INI)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-9751","authenticated-orcid":false,"given":"Yihe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"International Neuroscience Institute (China\u2010INI)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"International Neuroscience Institute (China\u2010INI)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-1026","authenticated-orcid":false,"given":"Yongzhi","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"International Neuroscience Institute (China\u2010INI)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-5252","authenticated-orcid":false,"given":"Guoguang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"International Neuroscience Institute (China\u2010INI)  Beijing 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