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Auditory steady\u2010state responses (ASSRs) to repetitive 40\u2010 and 80\u2010Hz stimuli are widely used measures of gamma\u2010band oscillations (GBOs) relevant to cognition, but have not yet been investigated in JME. To address this gap, we examined 40\u2010 and 80\u2010Hz ASSRs using magnetoencephalography and their relationship with cognitive function in JME.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross\u2010sectional case\u2013control study, we recorded ASSRs in 16 patients with JME and 16 age\u2010 and sex\u2010matched healthy controls (HC). Evoked power and phase\u2010locking factor (PLF) were quantified from magnetic resonance imaging\u2010based source estimates in the bilateral primary auditory cortices and compared between groups using linear mixed\u2010effects models (LMMs). Cognitive function was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Within the JME group, associations between RBANS indices and ASSR measures were examined using age\u2010 and sex\u2010adjusted linear regression. Where applicable,\n                      <jats:italic>p<\/jats:italic>\n                      values were adjusted using the Benjamini\u2013Hochberg false discovery rate (FDR) procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LMMs showed lower evoked power and PLF in JME than in HC (both group effects\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among the five RBANS indices, only the Attention Index was lower in JME (FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Within the JME group, the Attention Index was positively associated with both measures (evoked power:\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u200916.65, 95% confidence interval [CI], 5.81 to 27.49; PLF:\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u200938.82, 95% CI, 13.82 to 63.83; both FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), whereas other indices showed no significant associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Gamma\u2010band ASSRs were reduced in JME and were consistently associated with attentional performance across evoked power and PLF. These exploratory findings suggest that gamma\u2010band ASSRs may help investigate network\u2010level mechanisms, potentially involving thalamocortical dysfunction that link gamma synchronization to attentional performance in JME.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Juvenile myoclonic epilepsy (JME) is associated with cognitive difficulties beyond seizures, but the underlying brain physiology is not fully understood. Using magnetoencephalography, we found that patients with JME showed weaker gamma\u2010band auditory steady\u2010state responses (ASSRs) than healthy participants. Within the JME group, stronger and more synchronized responses were associated with better attention scores, suggesting that gamma\u2010band brain activity may be linked to attentional performance in JME. Together, these findings indicate that ASSRs may provide a useful window into brain mechanisms related to cognitive difficulties, particularly those involving attention, in JME.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi4.70330","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:26:23Z","timestamp":1788495983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Auditory gamma\u2010band synchronization and attentional performance in juvenile myoclonic epilepsy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1701-356X","authenticated-orcid":false,"given":"Ryo","family":"Mitoma","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Neuropsychiatry, Faculty of Life Sciences Kumamoto University  Kumamoto 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