{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:34:47Z","timestamp":1791027287630,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T00:00:00Z","timestamp":1312243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Bulimia nervosa (BN) is characterized by dysregulation of impulse control, in other words, uncontrolled eating. Functional neuroimaging studies have been sparse and have used variable methodologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirteen medication\u2010free female BN patients and 13 female healthy controls were investigated by functional magnetic resonance imaging using a disease\u2010specific food paradigm. Stimuli were rated after the scanning procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bulimia nervosa patients showed increased fear ratings and a trend for increased disgust. Magnetic resonance imaging data of 10 BN patients could be analysed. Three BN patients had to be excluded from the analysis because of minimal blood oxygen level dependent signals. Compared with healthy controls, BN patients showed less activation of the anterior cingulate cortex, which extended into the lateral prefrontal cortex. Furthermore, the right temporal pole showed decreased reactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study substantiates a key role of lateral prefrontal dysfunction in BN, a brain region involved in impulse control. Furthermore, the anterior cingulate cortex, which plays a key role in emotion processing, is dysfunctional. A major limitation of this study is the small sample size. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd and Eating Disorders Association.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.1150","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T07:16:47Z","timestamp":1312269407000},"page":"447-453","source":"Crossref","is-referenced-by-count":28,"title":["Frontocingular Dysfunction in Bulimia Nervosa when Confronted with Disease\u2010specific Stimuli"],"prefix":"10.1002","volume":"19","author":[{"given":"Andreas A.B.","family":"Joos","sequence":"first","affiliation":[{"name":"University of Freiburg Department of Psychosomatic Medicine and Psychotherapy  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Saum","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychosomatic Medicine and Psychotherapy  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"Zeeck","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychosomatic Medicine and Psychotherapy  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniy","family":"Perlov","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychiatry and Psychotherapy Section for Experimental Neuropsychiatry  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkmar","family":"Glauche","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Neurology  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychosomatic Medicine and Psychotherapy  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Freyer","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychiatry and Psychotherapy Section for Experimental Neuropsychiatry  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Sandholz","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychosomatic Medicine and Psychotherapy  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Unterbrink","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychosomatic Medicine and Psychotherapy  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger Tebartz","family":"van Elst","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychiatry and Psychotherapy Section for Experimental Neuropsychiatry  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"T\u00fcscher","sequence":"additional","affiliation":[{"name":"University of Freiburg Department of Psychiatry and Psychotherapy Section for Experimental Neuropsychiatry  Freiburg Germany"},{"name":"University of Freiburg Department of Neurology  Freiburg Germany"},{"name":"University of Mainz Department of Psychiatry and Psychotherapy  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1506","article-title":"Regional cerebral glucose metabolism in bulimia nervosa","volume":"149","author":"Andreason P. 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