{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:22:49Z","timestamp":1759335769054},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T00:00:00Z","timestamp":1389139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to gain further understanding of placebo response in binge eating disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We pooled participant\u2010level data from 10 double\u2010blind, placebo\u2010controlled, randomized trials of medications for binge eating disorder. The primary outcomes were response (75% reduction in binge eating episodes), cessation of binge eating episodes, change in mean weekly binge eating episodes and binge eating episodes per week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 234 participants receiving placebo, 89 (38%) were responders and 59 (26%) attained cessation. Placebo\u2010treated participants significantly reduced their binge eating. The mean (SD) binge eating episodes per week at baseline was 5.2 (3.2) and at endpoint was 2.2 (2.6). Lower baseline binge eating episode frequency and longer study participation were significantly associated with response and cessation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Less severe eating pathology at baseline was associated with higher placebo response and cessation rates. Future clinical trials may want to stipulate that participants exceed a threshold of illness severity, which may lead to better placebo and drug separation. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd and Eating Disorders Association.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2277","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T10:46:42Z","timestamp":1389178002000},"page":"140-146","source":"Crossref","is-referenced-by-count":24,"title":["Placebo Response in Binge Eating Disorder: A Pooled Analysis of 10 Clinical Trials from One Research Group"],"prefix":"10.1002","volume":"22","author":[{"given":"Thomas J.","family":"Blom","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Lindner Center of HOPE  Mason OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J.","family":"Mingione","sequence":"additional","affiliation":[{"name":"Lindner Center of HOPE  Mason OH USA"},{"name":"Department of Psychology University of Cincinnati  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna I.","family":"Guerdjikova","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Lindner Center of HOPE  Mason OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Paul E.","family":"Keck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Lindner Center of HOPE  Mason OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Welge","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"McElroy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati OH USA"},{"name":"Lindner Center of HOPE  Mason OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1113"},{"key":"e_1_2_5_4_1","article-title":"Antidepressants versus placebo for people with bulimia nervosa","volume":"4","author":"Bacaltchuk J.","year":"2003","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-2917-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10207"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2012.01340.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.3.262"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324635.49971.3d"},{"key":"e_1_2_5_10_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Patient Edition with Psychotic Screen (SCID\u2010I\/P W\/PSY SCREEN)","author":"First M. B.","year":"2002"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.899"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e328329c7b5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20946"},{"key":"e_1_2_5_15_1","first-page":"218","volume-title":"ECDEU Assessment Manual for Psychopharmacology\u2013Revised (DHEW Publ No ADM 76\u2013338)","author":"Guy W.","year":"1976"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/76.2.297"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11r07485"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20287"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.11.020"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.06.005"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200202000-00007"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06191"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3282f50c36"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2011.03.001"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.255"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.6.1004"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0306"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S25574"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20876"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0711"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n1209"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.333"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eatbeh.2007.03.006"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10202"},{"key":"e_1_2_5_37_1","volume-title":"Eating Inventory Manual","author":"Stunkard A. J.","year":"1988"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0807"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10203"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.14.1840"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20719"}],"container-title":["European Eating Disorders Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ferv.2277","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/erv.2277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:30:02Z","timestamp":1696570202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/erv.2277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/erv.2277"],"URL":"https:\/\/doi.org\/10.1002\/erv.2277","archive":["Portico"],"relation":{},"ISSN":["1072-4133","1099-0968"],"issn-type":[{"value":"1072-4133","type":"print"},{"value":"1099-0968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,8]]}}}