{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:18:06Z","timestamp":1789244286923,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T00:00:00Z","timestamp":1464652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004350","name":"Studienstiftung des Deutschen Volkes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Autonomic nervous system function is altered in eating disorders. We aimed to quantify differences in resting state vagal activity, indexed by high\u2010frequency heart rate variability comparing patients with <jats:italic>bulimia nervosa<\/jats:italic> (BN) and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search of the literature to identify studies eligible for inclusion and meta\u2010analytical methods were applied. Meta\u2010regression was used to identify potential covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies reporting measures of resting high\u2010frequency heart rate variability in individuals with BN (<jats:italic>n<\/jats:italic>\u2009=\u2009137) and controls (<jats:italic>n<\/jats:italic>\u2009=\u2009190) were included. Random\u2010effects meta\u2010analysis revealed a sizeable main effect (<jats:italic>Z<\/jats:italic>\u2009=\u20092.22, <jats:italic>p\u2009=\u2009.03<\/jats:italic>; Hedge's <jats:italic>g<\/jats:italic>\u2009=\u20090.52, 95% CI [0.06;0.98]) indicating higher resting state vagal activity in individuals with BN. Meta\u2010regression showed that body mass index and medication intake are significant covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Findings suggest higher vagal activity in BN at rest, particularly in unmedicated samples with lower body mass index. Potential mechanisms underlying these findings and implications for routine clinical care are discussed. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd and Eating Disorders Association.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2454","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T09:33:04Z","timestamp":1464687184000},"page":"355-365","source":"Crossref","is-referenced-by-count":31,"title":["A Meta\u2010analysis on Resting State High\u2010frequency Heart Rate Variability in Bulimia Nervosa"],"prefix":"10.1002","volume":"24","author":[{"given":"Stephanie K. 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