{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:22:26Z","timestamp":1783441346382,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Union's Seventh Framework Programme","award":["245009"],"award-info":[{"award-number":["245009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Euro Eating Disorders Rev"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In anorexia nervosa (AN) hypercortisolism has been described using urine, plasma and saliva samples as short\u2010term markers for the hypothalamic\u2013pituitary\u2013adrenal (HPA)\u2010axis. Here, for the first time, we analyse hair cortisol concentration (HCC) as a marker for long\u2010term integrated cortisol secretion in female patients with AN compared to female healthy controls (HC) and female psychiatric controls (PC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HCC was assessed in 22 female adolescent psychiatric inpatients with AN compared to 20 female HC and to 117 female PC of the same age range. For further analyses we examined the associations of age and body mass index (BMI) with HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Log HCC was lower in AN\u2010patients compared to HC (<jats:italic>p<\/jats:italic>\u2009=\u20090.030). BMI\u2010standard deviation scores (SDS) but not age correlated with log HCC (BMI\u2010SDS: <jats:italic>r<\/jats:italic>\u2009=\u20090.19, bias corrected accelerated 95% confidence interval: [.04, .34], <jats:italic>p<\/jats:italic>\u2009=\u20090.015; age: <jats:italic>r<\/jats:italic>\u2009=\u20090.10, bias corrected accelerated 95% confidence interval: [\u2212.07, .25], <jats:italic>p<\/jats:italic>\u2009=\u20090.213) when combining AN, HC and PC samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We find lower HCC in AN, compared to HC and PC, respectively. Based on the relationship between HCC and BMI\u2010SDS across AN, HC and PC, we argue that HCC might not capture endocrine alterations because of AN pathology\u2010related processes but rather shows consistent relationships with BMI, which extent even to the very low range of BMI values, as present in AN patients. Alternatively, incorporation of cortisol into the hair follicle might have been compromised because of trophic hair follicle disturbances that had been reported in AN patients, previously. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd and Eating Disorders Association.<\/jats:p><\/jats:sec>","DOI":"10.1002\/erv.2466","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T05:53:27Z","timestamp":1470894807000},"page":"531-535","source":"Crossref","is-referenced-by-count":22,"title":["Hair Cortisol Concentrations in Adolescent Girls with Anorexia Nervosa are Lower Compared to Healthy and Psychiatric Controls"],"prefix":"10.1002","volume":"24","author":[{"given":"Manuel","family":"F\u00f6cker","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics LVR Klinikum, Universit\u00e4tsklinikum Essen (A\u00f6R)  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Stalder","sequence":"additional","affiliation":[{"name":"Department of Biopsychology Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Kirschbaum","sequence":"additional","affiliation":[{"name":"Department of Biopsychology Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics LVR Klinikum, Universit\u00e4tsklinikum Essen (A\u00f6R)  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederike","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics LVR Klinikum, Universit\u00e4tsklinikum Essen (A\u00f6R)  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"de Zwaan","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy Hannover Medical School (MHH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Hebebrand","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics LVR Klinikum, Universit\u00e4tsklinikum Essen (A\u00f6R)  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triinu","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics LVR Klinikum, Universit\u00e4tsklinikum Essen (A\u00f6R)  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics LVR Klinikum, Universit\u00e4tsklinikum Essen (A\u00f6R)  Essen Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy Hannover Medical School (MHH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2011.619239"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2012.654479"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.10.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1997.tb01545.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.08.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.11.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000138912"},{"key":"e_1_2_8_10_1","first-page":"151","article-title":"Acquired pili torti\u2014A structural hair shaft defect in anorexia nervosa","volume":"57","author":"Lurie R.","year":"1996","journal-title":"Cutis"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2011.04.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70180-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0723"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22375"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.12.016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.8"},{"key":"e_1_2_8_17_1","unstructured":"Sa\u00dfH. 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