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We conducted a meta\u2010analysis and systematic review of intolerance of uncertainty in eating disorders using Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines. We calculated random\u2010effects standardised mean differences (SMD) for studies utilising the Intolerance of Uncertainty Scale (IUS) and summarised additional studies descriptively. Women with eating disorders have significantly higher IUS scores compared with healthy controls (SMD\u2009=\u20091.90; 95% C.I. 1.24 to 2.56; <jats:italic>p<\/jats:italic>\u2009&lt;\u00a00.001). <jats:italic>Post hoc<\/jats:italic> meta\u2010analysis revealed significant differences when comparing women with anorexia nervosa with controls (SMD\u2009=\u20092.16; 95% C.I. 1.14 to 3.18; <jats:italic>p\u00a0&lt;<\/jats:italic>\u20090.001) and women with bulimia nervosa with controls (SMD\u2009=\u20092.03; 95% C.I. 1.30 to 2.75; <jats:italic>p\u00a0&lt;<\/jats:italic>\u20090.001). Our synthesis of findings suggests that intolerance of uncertainty may represent a vulnerability and maintenance factor for eating disorders and potential target of cognitive, behavioural, interoceptive and affective symptoms. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd and Eating Disorders Association.<\/jats:p>","DOI":"10.1002\/erv.2523","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:49:27Z","timestamp":1495586967000},"page":"329-343","source":"Crossref","is-referenced-by-count":161,"title":["Intolerance of Uncertainty in Eating Disorders: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8801-5172","authenticated-orcid":false,"given":"Melanie","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York NY USA"},{"name":"Institute of Child Health University College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Cristina","family":"Campione","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York NY USA"},{"name":"Child Psychopathology Unit, Scientific Institute IRCCS Eugenio Medea  Bosisio Parini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Wuensch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Micali","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai  New York NY USA"},{"name":"Institute of Child Health University College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381587"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2014.08.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.55.11.1247"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2013.01.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.21965"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(01)00092-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2008.12.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2012.01.011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2006.03.014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2005.04.012"},{"key":"e_1_2_6_12_1","article-title":"Characterizing the brain\u2010behavior basis of habit learning in women with eating disorders","volume":"73","author":"Celone K. 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